Table 3 Large families of transmembrane proteins with known domains
From: A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome
| Group* | No of genes | Pfam ID, SMART ID, reference | Typical domain organization | |
|---|---|---|---|---|
| (A) Channels | ||||
| Ligand-gated ion channel | 102 | PF02931, PF02932, lgc-* | unc-29 |
|
| lgc-1 |
| |||
| Potassium channel | 71 | PF07885, | twk-1 |
|
| Salkoff et al. | ||||
| Sodium channel | 46 | PF00858, | nhx-1 |
|
| PF00999, | unc-8 |
| ||
| PF01699 | ||||
| Innexin | 25 | PF00876 | Inx-1 |
|
| (B) Transporters | ||||
| Major facilitator superfamily MFS-1 | 117 | PF07690 | oct-1 |
|
| ABC transporter, | 52 | PF00664, | pgp-1 |
|
| transmembrane region, type 1 | PF06472, |
| ||
| Zhao et al. | haf-1 |
| ||
| Sugar (and other) transporter | 43 | PF00083 | hmit-1.1 |
|
| Amino acid transporter | 36 | PF00324, | aat-1 |
|
| PF01490 | unc-47 |
| ||
| (C) Enzymes | ||||
| Acyltransferase | 71 | PF01757 | oac-1 |
|
| UDP-glucuronosyl/UDP-glucosyltransferase | 67 | PF00201 | ugt-1 |
|
| AAA ATPase | 50 | SM00382 | rpt-1 |
|
| wht-1 |
| |||
| Peptidase | 49 | see Additional file7 | nas-17 |
|
| bli-4d |
| |||
| rom-1 |
| |||
| sup-17 |
| |||
| (D) Signaling | ||||
| GPCR | 143 | PF00002, | dop-1a |
|
| PF00003, | ||||
| PF08395 | ||||
| Kinase | 69 | PF00069, | ddr-1 |
|
| PF07714, | gcy-1 |
| ||
| SM00219 | ver-1 |
| ||
| SM00220 | ||||
| SM00221 | ||||
| ANF_receptor | 33 | PF01094 | nmr-1 |
|
| Guanylate and adenylate cyclase | 30 | PF00211, | gcy-1 |
|
| SM00044 | ||||
| (E) Trafficking | ||||
| t-SNARE | 10 | SM00397 | syn-1 |
|
| (F) Cell adhesion | ||||
| clc-like domain | 19 | PF07062, | clc-2 |
|
| clc-* | ||||
| Cadherin | 12 | PF00028, | cdh-1 |
|
| SM00112 |
| |||
| (G) ECM components | ||||
| Cuticlin | 34 | PF00100, | cutl-1 |
|
| SM00241 | ||||
| Collagen | 11 | PF01391 | col-47 |
|
| (H) Others | ||||
| Zinc finger | 56 | see Additional file7 | ztf-18 |
|
| Tetraspannin | 20 | PF00335 | tsp-1 |
|
| F-box | 14 | PF00646, | fbxb-11 |
|
| SM00256, | ||||
| PF07735 |
