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Table 3 Large families of transmembrane proteins with known domains

From: A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome

Group* No of genes Pfam ID, SMART ID, reference   Typical domain organization
(A) Channels     
Ligand-gated ion channel 102 PF02931, PF02932, lgc-* unc-29
    lgc-1
Potassium channel 71 PF07885, twk-1
   Salkoff et al.   
Sodium channel 46 PF00858, nhx-1
   PF00999, unc-8
   PF01699  
Innexin 25 PF00876 Inx-1
(B) Transporters     
Major facilitator superfamily MFS-1 117 PF07690 oct-1
ABC transporter, 52 PF00664, pgp-1
transmembrane region, type 1   PF06472,
   Zhao et al. haf-1
Sugar (and other) transporter 43 PF00083 hmit-1.1
Amino acid transporter 36 PF00324, aat-1
   PF01490 unc-47
(C) Enzymes     
Acyltransferase 71 PF01757 oac-1
UDP-glucuronosyl/UDP-glucosyltransferase 67 PF00201 ugt-1
AAA ATPase 50 SM00382 rpt-1
    wht-1
Peptidase 49 see Additional file7 nas-17
bli-4d
rom-1
sup-17
(D) Signaling     
GPCR 143 PF00002, dop-1a
   PF00003,   
   PF08395   
Kinase 69 PF00069, ddr-1
PF07714, gcy-1
SM00219 ver-1
SM00220   
SM00221   
ANF_receptor 33 PF01094 nmr-1
Guanylate and adenylate cyclase 30 PF00211, gcy-1
   SM00044   
(E) Trafficking     
t-SNARE 10 SM00397 syn-1
(F) Cell adhesion     
clc-like domain 19 PF07062, clc-2
   clc-*   
Cadherin 12 PF00028, cdh-1
   SM00112
(G) ECM components     
Cuticlin 34 PF00100, cutl-1
   SM00241   
Collagen 11 PF01391 col-47
(H) Others     
Zinc finger 56 see Additional file7 ztf-18
Tetraspannin 20 PF00335 tsp-1
F-box 14 PF00646, fbxb-11
   SM00256,   
   PF07735   
  1. *Subgroup names and comments were excerpted or modified from Pfam or InterPro descriptions.
  2. Detailed descriptions for these subgroups are available at Additional file7.
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