Table 3 Large families of transmembrane proteins with known domains

(A) Channels

Ligand-gated ion channel

102

PF02931, PF02932, lgc-*

unc-29

lgc-1

Potassium channel

71

PF07885,

twk-1

Salkoff et al.

Sodium channel

46

PF00858,

nhx-1

PF00999,

unc-8

PF01699

Innexin

25

PF00876

Inx-1

(B) Transporters

Major facilitator superfamily MFS-1

117

PF07690

oct-1

ABC transporter,

52

PF00664,

pgp-1

transmembrane region, type 1

PF06472,

Zhao et al.

haf-1

Sugar (and other) transporter

43

PF00083

hmit-1.1

Amino acid transporter

36

PF00324,

aat-1

PF01490

unc-47

(C) Enzymes

Acyltransferase

71

PF01757

oac-1

UDP-glucuronosyl/UDP-glucosyltransferase

67

PF00201

ugt-1

AAA ATPase

50

SM00382

rpt-1

wht-1

Peptidase

49

see Additional file7

nas-17

bli-4d

rom-1

sup-17

(D) Signaling

GPCR

143

PF00002,

dop-1a

PF00003,

PF08395

Kinase

69

PF00069,

ddr-1

PF07714,

gcy-1

SM00219

ver-1

SM00220

SM00221

ANF_receptor

33

PF01094

nmr-1

Guanylate and adenylate cyclase

30

PF00211,

gcy-1

SM00044

(E) Trafficking

t-SNARE

10

SM00397

syn-1

(F) Cell adhesion

clc-like domain

19

PF07062,

clc-2

clc-*

Cadherin

12

PF00028,

cdh-1

SM00112

(G) ECM components

Cuticlin

34

PF00100,

cutl-1

SM00241

Collagen

11

PF01391

col-47

(H) Others

Zinc finger

56

see Additional file7

ztf-18

Tetraspannin

20

PF00335

tsp-1

F-box

14

PF00646,

fbxb-11

SM00256,

PF07735