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Table 1 Top 25 GO categories overrepresented in LI of 0WexGF mice compared with GF mice

From: A microarray analysis of gnotobiotic mice indicating that microbial exposure during the neonatal period plays an essential role in immune system development

GOID

Term

Number of Probes

p_int

GO:0042254

ribosome biogenesis and assembly

92

< 1.0E-18

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

14

6.18E-08

GO:0048511

rhythmic process

19

1.16E-07

GO:0006954

inflammatory response

48

6.79E-07

GO:0030300

regulation of cholesterol absorption

5

1.09E-06

GO:0006610

ribosomal protein import into nucleus

10

1.61E-06

GO:0042157

lipoprotein metabolic process

8

2.00E-06

GO:0001558

regulation of cell growth

64

2.63E-06

GO:0007166

cell surface receptor linked signal transduction

50

2.68E-06

GO:0050766

positive regulation of phagocytosis

10

3.64E-06

GO:0060048

cardiac muscle contraction

11

5.07E-06

GO:0007417

central nervous system development

17

6.65E-06

GO:0007413

axonal fasciculation

8

1.32E-05

GO:0006911

phagocytosis, engulfment

7

1.52E-05

GO:0006310

DNA recombination

27

1.54E-05

GO:0002504

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

6

2.46E-05

GO:0006950

response to stress

30

2.84E-05

GO:0000165

MAPKKK cascade

21

3.24E-05

GO:0007585

respiratory gaseous exchange

12

3.92E-05

GO:0006816

calcium ion transport

44

4.33E-05

GO:0042593

glucose homeostasis

18

5.19E-05

GO:0006414

translational elongation

14

5.69E-05

GO:0030901

midbrain development

8

6.54E-05

GO:0045582

positive regulation of T cell differentiation

6

7.88E-05

GO:0007229

integrin-mediated signaling pathway

36

8.14E-05

  1. MGP analysis was performed on GO BP categories which contains 4 ~ 99 genes (“Number of Probes”). The categories were sorted according to the integrated p value (p_int) and the top 25 are represented. The categories related to antigen presentation are noted (e.g., “antigen processing and presentation of exogenous peptide antigen via MHC class II”, “inflammatory response”, “positive regulation of phagocytosis”, “phagocytosis, engulfment”, “antigen processing and presentation of peptide or polysaccharide antigen via MHC class II” and “positive regulation of T cell differentiation”).