Table 3 Persistent changes in gene expression induced by lead
Gene Symbol | Gene Title | Probe Set ID | Entrez Gene ID | Fold Increase | P-value |
|---|---|---|---|---|---|
MT1M | metallothionein 1M | 217546_at | 4499 | 18 | 1.03E-22 |
MT1G | metallothionein 1G | 204745_x_at | 4495 | 17.7 | 1.64E-27 |
MT1H | metallothionein 1H | 206461_x_at | 4496 | 14.2 | 6.96E-28 |
MT1X | metallothionein 1X | 208581_x_at | 4501 | 13.9 | 1.90E-26 |
| Â | Â | 204326_x_at | 4501 | 13 | 1.66E-25 |
MT1E | metallothionein 1E | 212859_x_at | 4493 | 10.9 | 4.23E-26 |
MT2A | metallothionein 2A | 212185_x_at | 4502 | 10.6 | 2.93E-27 |
MT1P2 | metallothionein 1 pseudogene 2 | 211456_x_at | 645745 | 9.55 | 2.96E-27 |
MT1F | metallothionein 1F | 217165_x_at | 4494 | 8.86 | 1.29E-24 |
| Â | Â | 213629_x_at | 4494 | 6.6 | 2.47E-21 |
| Â | Â | 210524_x_at | 4494 | 4.62 | 2.72E-19 |
MT1E///MT1H///MT1M///MT1P2 | metallothionein 1E///metallothionein 1H///metallothionein 1M///metallothionein 1 pseudogene 2 | 216336_x_at | 4493///4496///4499///645745 | 7.44 | 4.60E-23 |
EDNRB | endothelin receptor type B | 204273_at | 1910 | 11 | 1.11E-17 |
| Â | Â | 206701_x_at | 1910 | 6.6 | 8.42E-13 |
| Â | Â | 204271_s_at | 1910 | 5.99 | 3.32E-13 |
ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 212224_at | 216 | 4.37 | 6.93E-06 |
KITLG | KIT ligand | 226534_at | 4254 | 3.19 | 2.02E-09 |
TDO2 | tryptophan 2,3-dioxygenase | 205943_at | 6999 | 3.14 | 0.004728 |
TMEM158 | transmembrane protein 158 | 213338_at | 25907 | 2.96 | 6.16E-15 |
FAM70A | family with sequence similarity 70, member A | 219895_at | 55026 | 2.87 | 0.000112 |
PTGR1 | prostaglandin reductase 1 | 231897_at | 22949 | 2.86 | 3.65E-08 |
| Â | Â | 228824_s_at | 22949 | 2.74 | 4.81E-07 |
ARRDC4 | arrestin domain containing 4 | 225283_at | 91947 | 2.8 | 7.31E-11 |
AKR1C1 | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha) | 204151_x_at | 1645 | 2.68 | 0.000934 |
| Â | Â | 216594_x_at | 1645 | 2.28 | 3.79E-05 |
AKR1C2 | aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid) | 211653_x_at | 1646 | 2.47 | 4.10E-05 |
| Â | Â | 209699_x_at | 1646 | 2.28 | 5.27E-05 |
ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 204058_at | 4199 | 2.53 | 9.73E-07 |
| Â | Â | 204059_s_at | 4199 | 2.3 | 9.20E-08 |
SLC7A11 | solute carrier family 7, (cationic amino acid transporter, y + system) member 11 | 207528_s_at | 23657 | 2.58 | 3.45E-07 |
| Â | Â | 209921_at | 23657 | 2.42 | 7.46E-06 |
| Â | Â | 217678_at | 23657 | 2.37 | 4.72E-05 |
ASPH | aspartate beta-hydroxylase | 210896_s_at | 444 | 2.41 | 1.80E-11 |
| Â | Â | 209135_at | 444 | 2.5 | 3.04E-10 |
| Â | Â | 224996_at | 444 | 2.08 | 9.56E-08 |
| Â | Â | 225008_at | 444 | 1.87 | 4.93E-08 |
| Â | Â | 205808_at | 444 | 1.58 | 7.60E-05 |
| Â | Â | 242037_at | 444 | 1.57 | 1.32E-06 |
ENSG00000204134 | --- | 238727_at | --- | 2.23 | 0.000495 |
SLC12A8 | solute carrier family 12 (potassium/chloride transporters), member 8 | 219874_at | 84561 | 2.17 | 1.85E-08 |
PIR | pirin (iron-binding nuclear protein) | 207469_s_at | 8544 | 2.01 | 0.000561 |