Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells

Table 2 Gene set analysis using Kyoto encyclopedia of genes and genomes (KEGG) pathways

A
Function	KEGG pathway	cDNA	HU-6800	U133	U95
Cell cycle & DNA replication
	Cell cycle	0.019	0.019	< 0.001	< 0.001
	DNA replication	0.001	0.125	0.003	0.001
	Base excision repair	0.003	0.003	0.002	0.003
Cell junction
	Adherens junction	< 0.001	< 0.001	< 0.001	0.001
	Tight junction	0.004	0.003	0.002	0.006
	Gap junction	0.011	0.007	0.015	0.014
Cell adhesion molecules
	Focal adhesion	0.016	0.315	0.014	0.015
	Cell adhesion molecules	0.007	0.007	0.017	0.005
	Regulation of actin cytoskeleton	0.013	0.013	0.001	< 0.001
B		cDNA	HU-6800	U133	U95
Molecular pathway
	Integrin signaling pathway	< 0.001	0.004	0.004	0.001
	VEGF signaling pathway	0.003	< 0.001	< 0.001	< 0.001
	Phosphatidylinositol signaling	0.009	0.009	0.006	0.003
	Wnt signaling pathway	0.004	0.524	< 0.001	< 0.001
	Jak-STAT signaling pathway	0.034	0.034	< 0.001	0.003
	MAPK signaling pathway	0.017	0.017	0.002	0.003
	ErbB signaling pathway	0.014	0.005	0.021	0.014
	p53 signaling pathway	0.035	0.034	0.016	0.006

Adjusted p-value using using Benjamini and Hochberg method as represented in four microarray platforms (significance cutoff is adjusted p-value < 0.01).

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