Table 3 Differentially expressed miRNAs in B-cells from centenarians vs. controls
From: Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
miRNA | Up regulated in | Control counts (standard error) | Centenarian counts (standard error) | P values | Bonferonni adjusted p values | Fold change |
|---|---|---|---|---|---|---|
hsa-miR-122 | Centenarian | 19 (6.26) | 102 (6.39) | 1.06E-16 | 2.44E-14 | 5.83 |
hsa-miR-363* | Centenarian | 184 (23.30) | 837 (81.32) | 3.6E-112 | 8.2E-110 | 4.94 |
hsa-miR-345 | Centenarian | 59 (10.65) | 227 (32.69) | 9.84E-28 | 2.27E-25 | 4.18 |
hsa-miR-20b | Centenarian | 306 (25.72) | 1108 (240.38) | 7.7E-122 | 1.8E-119 | 3.93 |
hsa-miR-454 | Centenarian | 39 (6.55) | 126 (34.59) | 1.02E-13 | 2.36E-11 | 3.51 |
hsa-miR-1974 | Centenarian | 4515 (660.27) | 14179 (668.31) | 0 | 0 | 3.41 |
hsa-miR-223* | Centenarian | 580 (39.17) | 1800 (204.29) | 2.2E-167 | 5.1E-165 | 3.37 |
hsa-miR-99b | Centenarian | 97 (15.32) | 276 (83.78) | 2.15E-24 | 4.96E-22 | 3.09 |
hsa-miR-181a* | Centenarian | 627 (24.30) | 1641 (307.63) | 4.5E-123 | 1E-120 | 2.84 |
hsa-miR-363 | Centenarian | 4732 (260.52) | 11971 (2286.46) | 0 | 0 | 2.75 |
hsa-miR-21* | Centenarian | 2529 (286.89) | 6313 (1153.62) | 0 | 0 | 2.71 |
hsa-miR-92b* | Centenarian | 99 (11.67) | 245 (42.00) | 2.45E-18 | 5.66E-16 | 2.69 |
hsa-miR-20b* | Centenarian | 319 (77.91) | 708 (84.88) | 5.78E-42 | 1.33E-39 | 2.41 |
hsa-miR-148a | Centenarian | 11599 (1225.92) | 25583 (655.62) | 0 | 0 | 2.40 |
hsa-miR-1975 | Centenarian | 1654 (86.54) | 3529 (335.65) | 2.1E-188 | 4.9E-186 | 2.32 |
hsa-miR-502-3p | Centenarian | 191 (13.48) | 387 (14.66) | 4.03E-20 | 9.31E-18 | 2.20 |
hsa-miR-181c | Centenarian | 153 (6.46) | 310 (63.42) | 1.8E-16 | 4.15E-14 | 2.20 |
hsa-miR-1259 | Centenarian | 106 (25.78) | 210 (29.26) | 4.01E-11 | 9.27E-09 | 2.15 |
hsa-miR-148a* | Centenarian | 339 (46.74) | 656 (14.26) | 3.38E-30 | 7.82E-28 | 2.10 |
hsa-miR-192 | Centenarian | 7126 (1026.34) | 13754 (2446.01) | 0 | 0 | 2.10 |
hsa-miR-361-5p | Centenarian | 307 (20.35) | 587 (89.41) | 1.65E-26 | 3.81E-24 | 2.08 |
hsa-miR-9 | Centenarian | 341 (26.37) | 629 (37.72) | 3.8E-26 | 8.78E-24 | 2.00 |
hsa-miR-151-3p | Control | 4515 (1288.82) | 1352 (223.77) | 0 | 0 | 3.07 |
hsa-miR-151-5p | Control | 257 (72.35) | 80 (13.37) | 7.22E-20 | 1.67E-17 | 2.96 |