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Table 3 Differentially expressed miRNAs in B-cells from centenarians vs. controls

From: Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing

miRNA Up regulated in Control counts (standard error) Centenarian counts (standard error) P values Bonferonni adjusted p values Fold change
hsa-miR-122 Centenarian 19 (6.26) 102 (6.39) 1.06E-16 2.44E-14 5.83
hsa-miR-363* Centenarian 184 (23.30) 837 (81.32) 3.6E-112 8.2E-110 4.94
hsa-miR-345 Centenarian 59 (10.65) 227 (32.69) 9.84E-28 2.27E-25 4.18
hsa-miR-20b Centenarian 306 (25.72) 1108 (240.38) 7.7E-122 1.8E-119 3.93
hsa-miR-454 Centenarian 39 (6.55) 126 (34.59) 1.02E-13 2.36E-11 3.51
hsa-miR-1974 Centenarian 4515 (660.27) 14179 (668.31) 0 0 3.41
hsa-miR-223* Centenarian 580 (39.17) 1800 (204.29) 2.2E-167 5.1E-165 3.37
hsa-miR-99b Centenarian 97 (15.32) 276 (83.78) 2.15E-24 4.96E-22 3.09
hsa-miR-181a* Centenarian 627 (24.30) 1641 (307.63) 4.5E-123 1E-120 2.84
hsa-miR-363 Centenarian 4732 (260.52) 11971 (2286.46) 0 0 2.75
hsa-miR-21* Centenarian 2529 (286.89) 6313 (1153.62) 0 0 2.71
hsa-miR-92b* Centenarian 99 (11.67) 245 (42.00) 2.45E-18 5.66E-16 2.69
hsa-miR-20b* Centenarian 319 (77.91) 708 (84.88) 5.78E-42 1.33E-39 2.41
hsa-miR-148a Centenarian 11599 (1225.92) 25583 (655.62) 0 0 2.40
hsa-miR-1975 Centenarian 1654 (86.54) 3529 (335.65) 2.1E-188 4.9E-186 2.32
hsa-miR-502-3p Centenarian 191 (13.48) 387 (14.66) 4.03E-20 9.31E-18 2.20
hsa-miR-181c Centenarian 153 (6.46) 310 (63.42) 1.8E-16 4.15E-14 2.20
hsa-miR-1259 Centenarian 106 (25.78) 210 (29.26) 4.01E-11 9.27E-09 2.15
hsa-miR-148a* Centenarian 339 (46.74) 656 (14.26) 3.38E-30 7.82E-28 2.10
hsa-miR-192 Centenarian 7126 (1026.34) 13754 (2446.01) 0 0 2.10
hsa-miR-361-5p Centenarian 307 (20.35) 587 (89.41) 1.65E-26 3.81E-24 2.08
hsa-miR-9 Centenarian 341 (26.37) 629 (37.72) 3.8E-26 8.78E-24 2.00
hsa-miR-151-3p Control 4515 (1288.82) 1352 (223.77) 0 0 3.07
hsa-miR-151-5p Control 257 (72.35) 80 (13.37) 7.22E-20 1.67E-17 2.96
  1. All miRNA determined to be differentially expressed with a Bonferroni adjusted p-value < 0.05 and fold change > 2.0.