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Table 3 In vivo plasma concentrations of AR antagonist compounds on day 60, 4 hrs postdose, following daily oral administration

From: Dose-dependent effects of small-molecule antagonists on the genomic landscape of androgen receptor binding

 

Mouse Cp (nM)

Fold Free Cp/IC50

Total

Free

AR antagonism

VCaP proliferation

Compound 30 (25mpk)

38946

2520

18

27

Compound 26 (100mpk)

11324

622

11

14

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BMC Genomics

ISSN: 1471-2164

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