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Table 3 In vivo plasma concentrations of AR antagonist compounds on day 60, 4 hrs postdose, following daily oral administration

From: Dose-dependent effects of small-molecule antagonists on the genomic landscape of androgen receptor binding

  Mouse Cp (nM) Fold Free Cp/IC50
Total Free AR antagonism VCaP proliferation
Compound 30 (25mpk) 38946 2520 18 27
Compound 26 (100mpk) 11324 622 11 14