Table 3 Histopathological observations/changes

Liver

No significant findings

39.0%

33.3%

0.39

Mild fatty change

38.1%

31.4%

0.312

Mild to moderate fatty change

8.6%

7.6%

0.801

Moderate fatty change

8.6%

8.6%

n.d.

Moderate to severe fatty change

0.0%

1.9%

0.156

Severe fatty change

0.0%

0.0%

n.d.

Perivascular infiltration

2.9%

6.7%

0.196

Peri biliar ducts infiltration

3.8%^a

21.0%

<0.001

Necrotic foci w/infiltration

1.0%

0.0%

0.317

Mild congestion

0.0%

1.0%

0.317

Focal necrosis

0.0%

2.9%

0.082

Mild sinusoidal dilatation

0.0%

1.0%

0.317

Biliar ducts esclerosis

0.0%

2.9%

0.082

Biliar ducts proliferation

0.0%

0.0%

n.d.

Foci of inflammatory cells

0.0%

1.0%

0.317

Heart (ventricle)

No significant findings

99.0%

98.1%

0.562

Severe infiltration and myodegeneration

1.0%

1.0%

n.d.

Infiltration, no myodegeneration

0.0%

1.0%

0.317

Presence of melanin granules

0.0%

0.0%

n.d.

Mid-intestine and Pyloric caeca

No significant findings

100%

100%

n.d.

Distal intestine

No significant findings

97.1%

95.2%

0.472

Infiltration of submucosa and lamina propria, widened of lamina propria within folds (simple and complex), prominent goblet cells/low number of supranuclear vacuoles

2.9%

4.8%

0.472