TY - JOUR AU - Avula, Leela Rani AU - Knapen, Dries AU - Buckinx, Roeland AU - Vergauwen, Lucia AU - Adriaensen, Dirk AU - Van Nassauw, Luc AU - Timmermans, Jean-Pierre PY - 2012 DA - 2012/08/06 TI - Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammation JO - BMC Genomics SP - 377 VL - 13 IS - 1 AB - Although a number of intestinal inflammatory conditions pertain to the ileum, whole-genome gene expression analyses in animal models of ileal inflammation are lacking to date. Therefore, we aimed to identify and characterize alterations in gene expression in the acutely inflamed ileum of two murine models of intestinal inflammation, namely intestinal schistosomiasis and TNBS-induced ileitis, compared to healthy controls. To this end, we used whole-genome microarrays, followed by bioinformatics analyses to detect over-represented Kyoto Encyclopedia of Genes and Genomes pathways and Gene Ontology categories. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-13-377 DO - 10.1186/1471-2164-13-377 ID - Avula2012 ER -