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Table 3 Expression and secretome data of predicted protein hydrolases

From: The carbon starvation response of Aspergillus niger during submerged cultivation: Insights from the transcriptome and secretome

    

Transcriptomic data

 
    

Expressiona

 

Fold changesb

 

FDR q-valuesb

 

Secretome datac

Identifier

Gene

(Predicted) function

 

Expd

Day 1

Day 3

Day 6

 

Day 1

Day 3

Day 6

 

Day 1

Day 3

Day 6

 

Expd

Day 1

Day 3

Day 6

S P e present

                    

An01g00530

pepB

A4 family peptidase

 

0.6

84.9

32.5

113.9

 

148.1

56.7

198.8

 

1.4E-16

9.1E-16

5.9E-17

 

-

-

-

-

An14g04710

pepA

Aspartyl protease

 

1.4

180.1

34.7

70.5

 

130.2

25.1

51.0

 

1.9E-13

2.2E-11

2.2E-12

 

+++∗

++++++

++++++

++++++

An01g01750

 

Subtilisin-like serine protease

 

1.1

45.8

9.8

8.9

 

40.0

8.6

7.7

 

2.3E-14

9.5E-12

1.5E-11

 

-

+++

++++

+++

An02g01550

 

Secreted serine protease

 

2.4

63.2

25.3

6.0

 

26.0

10.4

2.5

 

8.6E-10

4.8E-08

9.8E-04

 

++∗

++++

++++∗

-

An08g04640

 

Lysosomal pepstatininsensitive protease

 

1.1

16.2

8.0

10.6

 

14.3

7.1

9.3

 

4.0E-12

1.5E-10

3.2E-11

 

+∗

++++

+++++

++++

An06g00190

 

Lysosomal pepstatininsensitive protease

 

2.3

31.5

27.2

25.9

 

13.4

11.6

11.0

 

1.1E-10

2.3E-10

2.8E-10

 

+++∗

++++

+++++

++++

An03g01010

 

Lysosomal pepstatininsensitive protease

 

1.2

14.9

3.2

4.2

 

12.7

2.7

3.6

 

1.2E-09

4.8E-05

3.6E-06

 

+∗

+++∗

+++∗

+++∗

An02g04690

 

Serine-typecarboxypeptidase I

 

6.4

64.7

31.7

34.9

 

10.1

4.9

5.4

 

9.7E-10

8.4E-08

4.2E-08

 

++

++++∗

+++++

+++++

An12g05960

 

Dipeptidyl peptidase II

 

1.0

9.2

4.1

2.7

 

9.0

4.0

2.6

 

2.8E-11

7.3E-09

4.78-07

 

-

+++∗

++++

++++

An07g08030

pepF

Serine carboxypeptidase

 

0.8

7.0

4.2

6.3

 

8.6

5.2

7.7

 

1.2E-11

2.7E-10

2.2E-11

 

-

++∗

+++

+++∗

An11g06350

 

Carboxypeptidase

 

1.1

8.3

3.6

1.7

 

7.9

3.4

1.6

 

5.0E-11

2.1E-08

5.0E-04

 

-

-

-

-

An09g03780

pepD

Subtilisin-like serineprotease

 

0.5

3.0

0.6

0.7

 

5.8

1.1

1.4

 

2.2E-11

1.6E-01

2.4E-03

 

-

-

-

-

An12g03300

 

Aspartic protease

 

0.7

3.4

0.5

0.4

 

5.0

0.7

0.7

 

1.1E-08

1.2E-02

1.0E-02

 

++∗

+++

  

An15g06280

 

Aspartic proteinase[truncated ORF]

 

5.8

25.2

33.2

22.4

 

4.3

5.7

3.8

 

4.1E-09

6.1E-10

1.2E-08

 

++∗

+++∗

++++∗

++++∗

An16g09010

 

Carboxypeptidase I[putative frameshift]

 

0.6

2.2

3.6

4.7

 

4.0

6.4

8.4

 

2.5E-09

8.8E-11

1.8E-11

 

-

-

+++∗

+++

An14g00620

 

Aminopeptidase

 

5.3

20.4

14.7

14.3

 

3.8

2.8

2.7

 

4.6E-09

1.3E-07

1.8E-07

 

-

-

-

-

An07g03880

pepC

Serine proteinase

 

31.1

111.2

101.5

91.5

 

3.6

3.3

2.9

 

8.5E-12

2.2E-11

6.3E-11

 

++∗

-

-

-

An07g10060

 

Proteinase B inhibitor

 

4.2

13.1

17.0

19.5

 

3.1

4.1

4.7

 

1.1E-08

1.1E-09

3.5E-10

 

+++∗

-

-

-

An02g07210

pepE

Aspartic protease

 

30.4

83.9

57.8

57.2

 

2.8

1.9

1.9

 

1.4E-10

3.3E-08

3.9E-08

 

-

++++

+++∗

++∗

An15g07700

 

Aspergillopepsin IIprecursor

 

1.3

3.5

3.3

4.4

 

2.7

2.6

3.4

 

3.5E-07

5.2E-07

3.1E-08

 

-

-

-

-

An18g01320

 

Extracellular proteaseprecursor

 

21.9

54.8

14.7

4.9

 

2.5

0.7

0.2

 

1.8E-05

1.5E-02

6.8E-08

 

+++∗

++++

+++++∗

++++

An02g13740

 

Gly-X carboxypeptidaseprecursor

 

1.9

4.4

4.2

4.4

 

2.3

2.2

2.4

 

9.5E-09

2.1E-08

8.6E-09

 

-

-

-

-

An03g01660

 

Vacuolar aminopeptidase Y

 

9.1

19.2

17.4

17.5

 

2.1

1.9

1.9

 

3.1E-09

1.9E-08

1.5E-08

 

++∗

-

-

-

An08g08750

cpY

Carboxypeptidase

 

33.8

67.9

53.8

51.3

 

2.0

1.6

1.5

 

1.0E-08

1.3E-06

4.2E-06

 

++∗

-

-

-

An14g03250

 

Aspergillopepsin II

 

0.7

1.2

0.9

1.6

 

1.7

1.3

2.2

 

2.5E-04

3.0E-02

3.1E-06

 

-

+++∗

-

-

An07g10410

 

Metalloprotease

 

1.2

1.3

7.5

16.1

 

1.1

6.5

13.9

 

2.8E-01

8.3E-11

1.6E-12

 

-

-

-

-

S P e absent

                    

An01g00370

 

Aspergillopepsin

 

0.8

89.0

16.8

10.0

 

110.2

20.8

12.3

 

3.6E-14

4.9E-12

3.9E-11

 

++∗

+++++

+++++

+++++

An02g00090

 

Prolidase

 

0.4

20.4

22.7

7.6

 

53.2

59.4

19.8

 

1.2E-14

1.0E-14

1.9E-13

 

-

-

-

-

An14g02080

 

Prolidase

 

1.8

18.0

6.8

4.1

 

9.7

3.7

2.2

 

4.4E-09

2.8E-06

3.8E-04

 

-

-

-

-

An09g02830

 

Acylaminoacyl-peptidase

 

4.3

39.7

18.0

9.9

 

9.2

4.2

2.3

 

1.8E-12

3.0E-10

1.6E-07

 

-

-

-

-

An17g00390

 

Aminopeptidase

 

4.6

27.7

10.2

7.4

 

6.0

2.2

1.6

 

3.2E-11

5.1E-07

1.2E-04

 

-

-

-

-

An18g03980

 

Glutamatecarboxypeptidase II

 

3.2

19.0

13.8

13.7

 

5.9

4.3

4.3

 

3.3E-12

3.3E-11

3.4E-11

 

-

-

-

-

An01g01720

 

Bleomycin hydrolase

 

0.6

3.3

1.4

1.0

 

5.4

2.3

1.7

 

1.6E-10

8.4E-07

1.0E-04

 

-

-

-

-

An07g06490

 

Insulin-degrading enzyme

 

0.4

2.1

1.1

1.1

 

5.2

2.7

2.7

 

8.5E-11

2.9E-08

3.7E-08

 

-

-

-

-

An11g05920

 

Prolidase

 

0.9

4.6

1.5

1.3

 

5.0

1.6

1.4

 

5.2E-08

9.1E-03

5.3E-02

 

-

-

-

-

An11g02950

 

Calpain family cysteine protease

 

0.9

3.6

3.2

1.7

 

4.3

3.7

2.0

 

9.8E-10

3.4E-09

6.0E-06

 

-

-

-

-

An01g14920

 

Metallopeptidase

 

0.5

1.8

1.3

1.1

 

3.9

2.8

2.3

 

1.1E-09

4.0E-08

4.1E-07

 

-

-

-

-

An11g01970

 

Pyroglutamyl peptidase

 

2.1

8.2

6.0

6.8

 

3.9

2.8

3.2

 

1.0E-11

2.4E-10

6.2E-11

 

-

-

-

-

An14g01530

 

Subtilisin-like serine proteases

 

0.5

2.0

1.1

0.7

 

3.7

2.1

1.3

 

9.9E-09

7.0E-06

2.6E-02

 

-

-

-

-

An09g06800

 

Leucyl aminopeptidase

 

10.9

40.3

37.7

33.4

 

3.7

3.5

3.1

 

1.3E-11

2.5E-11

8.2E-11

 

-

-

-

-

An12g01820

 

Ubiquitin carboxyl-terminal hydrolase

 

0.8

2.6

1.7

1.1

 

3.4

2.2

1.5

 

8.1E-10

2.0E-07

4.4E-04

 

-

-

-

-

An01g08470

 

Ubiquitin carboxyl-terminal hydrolase

 

1.8

5.9

7.5

7.4

 

3.3

4.2

4.1

 

6.1E-10

8.3E-11

9.6E-11

 

-

-

-

-

An04g00410

 

Dipeptidyl peptidase III

 

17.0

51.9

37.8

29.6

 

3.1

2.2

1.7

 

9.6E-10

5.6E-08

3.4E-06

 

-

-

-

-

An16g08150

 

Dipeptidyl-peptidase V

 

10.5

26.0

17.4

17.2

 

2.5

1.7

1.6

 

4.3E-09

4.1E-06

4.9E-06

 

-

-

-

-

An18g02980

 

Endopeptidase

 

4.6

10.4

8.3

8.2

 

2.3

1.8

1.8

 

4.0E-09

2.0E-07

2.6E-07

 

-

-

-

-

An04g06940

prtT

Transcriptional activator of proteases

 

5.4

58.4

35.2

24.9

 

10.8

6.5

4.6

 

5.7E-12

9.8E-11

1.0E-09

 

-

-

-

-

  1. amRNA abundance relative (%) to the gamma-actin (An15g00560) encoding transcript during exponential growth.
  2. bFold changes and FDR q-values for comparisons with transcriptome data from the exponential growth phase.
  3. cProtein abundance in filtrates: (-) not detected; (+) < 5 ng ml−1; (++) < 50 ng ml−1; (+++) < 250 ng ml−1; (++++) < 1 μ g ml−1; (+++++) < 4 μ g ml−1; (++++++) > 4 μ g ml−1; (∗) biological and/or technical relative standard deviation above 100 and 50, respectively.
  4. dExponential growth phase.
  5. eSignal peptide sequence prediction[43].
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