TY - JOUR AU - Geeleher, Paul AU - Huang, Stephanie R. AU - Gamazon, Eric R. AU - Golden, Aaron AU - Seoighe, Cathal PY - 2012 DA - 2012/08/10 TI - The regulatory effect of miRNAs is a heritable genetic trait in humans JO - BMC Genomics SP - 383 VL - 13 IS - 1 AB - microRNAs (miRNAs) have been shown to regulate the expression of a large number of genes and play key roles in many biological processes. Several previous studies have quantified the inhibitory effect of a miRNA indirectly by considering the expression levels of genes that are predicted to be targeted by the miRNA and this approach has been shown to be robust to the choice of prediction algorithm. Given a gene expression dataset, Cheng et al. defined the regulatory effect score (RE-score) of a miRNA as the difference in the gene expression rank of targets of the miRNA compared to non-targeted genes. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-13-383 DO - 10.1186/1471-2164-13-383 ID - Geeleher2012 ER -