TY - JOUR AU - Li, Gang AU - Liu, Ka AU - Jiao, Shasha AU - Liu, Haibo AU - Blair, Hugh T. AU - Zhang, Peng AU - Cui, Xiaoran AU - Tan, Pingping AU - Gao, Jianfeng AU - Ma, Runlin Z. PY - 2012 DA - 2012/08/16 TI - A physical map of a BAC clone contig covering the entire autosome insertion between ovine MHC Class IIa and IIb JO - BMC Genomics SP - 398 VL - 13 IS - 1 AB - The ovine Major Histocompatibility Complex (MHC) harbors genes involved in overall resistance/susceptibility of the host to infectious diseases. Compared to human and mouse, the ovine MHC is interrupted by a large piece of autosome insertion via a hypothetical chromosome inversion that constitutes ~25% of ovine chromosome 20. The evolutionary consequence of such an inversion and an insertion (inversion/insertion) in relation to MHC function remains unknown. We previously constructed a BAC clone physical map for the ovine MHC exclusive of the insertion region. Here we report the construction of a high-density physical map covering the autosome insertion in order to address the question of what the inversion/insertion had to do with ruminants during the MHC evolution. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-13-398 DO - 10.1186/1471-2164-13-398 ID - Li2012 ER -