Figure 3

Genome-wide linkage analysis for body weight loss after H1N1 infection identifies time-dependent QTLs. Analysis of body weight from day 1 (A), day 2 (B), day 3 (C), day 4 (D), day 5 (E), day 6 (F) and day 7 (G) after PR8 infection revealed time-dependent QTLs. A significant QTL is located on chromosome 5 and suggestive QTLs are observed on chromosomes 2, 6, 9, 10, 16 and 17. Dead or euthanized mice were included for the analysis by manually setting their body weight to 75%. Interval mapping is shown across the entire genome as blue line representing the LRS scores; green line: DBA/2J alleles increase trait values; red line: C57BL/6J alleles increase trait values. Upper x-axis shows mouse chromosomes, lower x-axis shows physical map in mega bases for each chromosome, y-axis represents LRS score. The horizontal lines mark the genome-wide significant thresholds at p<0.05 (red line) and suggestive thresholds at p<0.37 (gray line).