Figure 8

Detailed maps of QTLs contributing to host susceptibility and resistance to PR8 influenza A infection. Interval mapping was performed for chromosomes 2 (A), 5 (B), 16 (C), 17 (D) and 19 (E). The critical intervals were selected based on the peak shapes and the bootstrap signals: Qivr2-1 (56–68 Mb), Qivr5 (140–153 Mb), Qivr16 (64–78 Mb), Qivr17-2 (30–44 Mb) and Qivr19 (37–45 Mb). The Qivr intervals are delineated by red arrows. The yellow bars represent the frequencies of peak LRS using bootstrap analysis. The multicolored chatters along the top of the graph are hyperlinks to sites with additional genetic and sequence information. The orange chatter along the x-axis indicates the density of SNPs present in the BXD strains. Interval mapping is shown across the entire genome as blue line representing the LRS scores; green line: DBA/2J alleles increase trait values; red line: C57BL/6J alleles increase trait values. Upper x-axis shows mouse chromosomes, lower x-axis shows physical map in mega bases for each chromosome, y-axis represents LRS score. The horizontal lines mark the genome-wide significant thresholds at p<0.05 (red line) and suggestive thresholds at p<0.37 (gray line).