Table 3 Functional groups observed in up-regulated genes in virulent strains related to control strains after 15, 30 and 60 min of incubation in blood ^a

Base-excision repair

+

-

-

POL30, POL31, RAD27, APN1, OGG1

Vacuole organization

+

+

-

CMD1, VPS3, CUP5, VTC1, SFK1, VID24/ MD1/ VPS45/ TRX2/ TRX1/ VAC7/ TPM1/ VTC3/

Xenobiotic transporter

+

-

-

PDR5, SNQ2, PDR12

Amino acid biosynthetic process/ Amine biosynthetic process/ Nitrogen compound biosynthetic process

-

+

+

ARO4/ ARO3/ LYS4/ HIS1/ ARG5/ARG6/ SER3/ILV1/ SER33/ HIS5/ LYS1/ TRP3/ ARG1/ ARG8/ LEU9/ ORT1/ SAM4

Amino acid metabolic process

-

+

+

ADH5/ ARO4/ ARO3/ LYS4/ HIS1/ ARG5/ARG6/ SER3/ ILV1/ADH4/ SER33/ HIS5/ LYS1/ URA2/ TRP3/ MSE1/ ARG1/ ARG8/ LEU9/ ORT1/ SAM4/

Phosphatase activity

-

+

+

PTC3/ PHO3/ PHO5/ DPP1/ LPP1/ SDT1/ PHO12/ INP51/ SAP185/ SAC1/ PPZ1/ TSL1/ YMR087WTPS3/ FCP1/ YNL217W/ PHO12

Transmembrane transporter activity

-

+

-

CTP1/ GGC1/ ATP17/ GNP1/ PIC2/ HXT10/ VPS73/ ZRT1/ TPO2/ TNA1/ AVT1/ VMA5/ ZRT3/ YBT1/ AQY2/ SMF3/ ZRT2/ ATR1/ ITR2/ ORT1/ ODC2/ PDR12/ YMC1/ ANT1/ TPO3/

Cell redox homeostasis

-

-

+

TTR1/ TRX2/ TRX1/ TSA1/ GLR1/ YNL134C/ TPS1/ PGM2/ GRE2/ MXR1/ PDI1/ UBA1/ LYS20/ AHP1/ TKL1/TAL1/ ADH6/ CYS3