Table 3 Identification of genes putatively involved in the biosynthesis of various vitamins and siroheme

Thiamine biosynthesis

Fphi_0086 (251 aa)

Thiazole biosynthesis adenylyltransferase (ThiF)

Mrub_1727, 266 aa, 38%, 7e-41

Fphi_0087 (485 aa)

Fused protein Phosphomethylpyrimidine kinase (ThiD)/Thiamine-phosphate pyrophosphorylase (ThiE)

lpg1568, 495 aa, 35%, 1e-72

Fphi_0088 (259 aa)

Thiazole synthase (ThiG)

lpg1567, 263 aa, 58%, 2e-86

Fphi_1923 (66 aa)

Thiamine biosynthesis protein (ThiS)

IL0768, 66 aa, 32%, 1e-04

Fphi_0089 (350 aa)

Thiamine biosynthesis oxidoreductase (ThiO)

Kkor_0127, 351 aa, 34%, 3e-47

Fphi_0090 (592 aa)

Thiamine biosynthesis protein (ThiC)

CV_0235, 632 aa, 72%, 0.0

Riboflavin biosynthesis

Fphi_0395 (306 aa)

Riboflavin kinase (RibF)

D11S_1924, 308 aa, 47%, 5e-69

Fphi_0713 (356 aa)

Riboflavin biosynthesis protein (RibD)

Acear_1431, 371 aa, 44%, 5e-79

Fphi_0714 (201 aa)

Riboflavin synthase, alpha subunit (RibC/RibE)

CLD_1677, 228 aa, 48%, 5e-41

Fphi_0715 (403 aa)

GTP cyclohydrolase II (RibA)

DEFDS_1098, 405 aa, 49%, 5e-104

Fphi_0716 (147 aa)

6,7-dimethyl-8-ribityllumazine synthase (RibH)

lpg1180, 155 aa, 56%, 3e-39

Folate biosynthesis

Fphi_0420 (282 aa)

Methenyltetrahydrofolate cyclohydrolase (FolD)

SULAZ_0428, 284 aa, 60%, 3e-87

Fphi_0547 (394 aa)

Dihydrofolate synthase (FolC)

Ssed_1653, 421 aa, 34%, 2e-45

Fphi_0600 (165 aa)

Dihydrofolate reductase (FolA)

BMD_4044, 161 aa, 54%, 7e-41

Fphi_1791 (184 aa)

Para-aminobenzoate synthase, amidotransferase component

Slin_0655, 205 aa, 38%, 4e-37

Fphi_1792 (587 aa)

Para-aminobenzoate synthase, aminase component

Csal_2692, 629 aa, 37%, 3e-99

Fphi_1794 (117 aa)

Dihydroneopterin aldolase (FolB)

WPa_0696, 125 aa, 32%, 1e-09

Fphi_1795 (421 aa)

Dihydropteroate synthase (FolKP)

RBE_0032, 438 aa, 35%, 4e-48

Biotin biosynthesis

Fphi_1798 (428 aa)

Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (BioA)

CBU_1008, 442 aa, 51%, 4e-121

Fphi_1799 (313 aa)

Biotin synthase (BioB)

CBU_1007, 321 aa, 61%, 7e-103

Fphi_1800 (372 aa)

8-amino-7-oxononanoate synthase (BioF)

Sde_3138, 397 aa, 38%, 6e-60

Fphi_1801 (244 aa)

Biotin biosynthesis protein (BioC)

CBU_1004, 248 aa, 28%, 2e-10

Fphi_1803 (226 aa)

Dethiobiotin synthase (BioD)

Sde_3135, 230 aa, 38%, 5e-37

Siroheme biosynthesis

Fphi_0284 (323 aa)

Porphobilinogen synthase (HemB)

Amet_0062, 324 aa, 60%, 1e-110

Fphi_0603 (469 aa)

Glutamyl-tRNA synthetase (GltX)

Fbal_2571, 470 aa, 60%, 2e-163

Fphi_0691 (300 aa)

Porphobilinogen deaminase (HemC)

APL_1010, 309 aa, 56%, 4e-86

Fphi_0945 (344 aa)

Uroporphyrinogen decarboxylase (HemE)

Rmag_1026, 347 aa, 50%, 1e-97

Fphi_1071 (414 aa)

Glutamyl-tRNA reductase (HemA)

PSPA7_5315, 422 aa, 35%, 2e-70

Fphi_1313 (252 aa)

Uroporphyrinogen-III synthase (HemD)

PSM_A0104, 613 aa, 31%, 1e-08

Fphi_1400 (400 aa)

Protoporphyrinogen oxidase (HemY/HemG)

Cphamn1_2137, 396 aa, 34%, 2e-58

Fphi_1812 (433 aa)

Glutamate-1-semialdehyde aminotransferase (HemL)

APJL_1583, 426 aa, 61%, 2e-151

Fphi_1842 (308 aa)

Coproporphyrinogen III oxidase (HemF)

Tcr_0017, 323 aa, 59%, 2e-106

Fphi_1900 (338 aa)

Ferrochelatase, protoheme ferro-lyase (HemH)

SMc04019, 342 aa, 50%, 7e-92