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Table 2 Gene ontology (GO) and KEGG annotation for representative clusters of differentially expressed genes

From: Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting

Cluster

Annotation

GO term (Biological Process, level 6 or 7) or KEGG pathway name

FDR p-value

1, 3 and 4 (731 genes)

GO

Positive regulation of protein metabolic process

6.0 E-3

Negative regulation of cellular macromolecule biosynthetic process

7.3 E-3

 

Triglyceride metabolic process

1.0 E-2

 

Negative regulation of gene expression

1.0 E-2

 

Proteolysis involved in cellular protein catabolic process

1.0 E-2

 

Negative regulation of kinase activity

1.5 E-2

 

Regulation of transcription, DNA-dependent

2.1 E-2

 

Protein phosphorylation

3.3 E-2

 

Antigen receptor-mediated signaling pathway

3.3 E-2

 

Regulation of phosphate metabolic process

3.4 E-2

 

Regulation of kinase activity

3.4 E-2

 

Regulation of I-kappaB kinase/NF-kappaB cascade

3.5 E-2

KEGG

Ubiquitin mediated proteolysis

1.0 E-2

 

Sphingolipid metabolism

1.8 E-2

 

PPAR signaling pathway

2.4 E-2

 

Fatty acid metabolism

4.6 E-2

 

Peroxisome

5.0 E-2

2 (557 genes)

GO

Monosaccharide catabolic process

2.5 E-2

DNA dependent DNA replication

3.6 E-3

 

Hexose metabolic process

1.1 E-2

 

Glucose metabolic process

1.4 E-2

  

Regulation of cell shape

1.5 E-2

  

DNA replication

1.5 E-2

  

Nucleoside triphosphate metabolic

2.3 E-2

 

KEGG

Glycolysis / Gluconeogenesis

4.9 E-4

  

Citrate cycle (TCA cycle)

8.9 E-4

6 (402 genes)

KEGG

Steroid biosynthesis

4.4 E-3

 

Glyoxylate and dicarboxylate metabolism

1.2 E-2

  

Pyruvate metabolism

3.3 E-2

5 and 7 (250 genes)

GO

Enzyme linked receptor protein signaling pathway

9.7 E-3

Regulation of cellular protein metabolic process

3.1 E-2

  

Negative regulation of macromolecule metabolic process

3.5 E-2

  

Transmembrane receptor protein serine/threonine kinase signaling pathway

3.6 E-2

  

Negative regulation of protein metabolic process

3.7 E-2

  

Positive regulation of cellular metabolic process

4.4 E-2

 

KEGG

PPAR signaling pathway

1.0 E-4

  

Glycerolipid metabolism

1.8 E-2

  

MAPK signaling pathway

4.6 E-2

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BMC Genomics

ISSN: 1471-2164

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