Table 2 Top 20 KEGG pathways based on gene number following PML knockdown
KEGG canonical pathway name | Gene number | Over-represent fold | q value |
|---|---|---|---|
Metabolic pathways | 95 | 3.129177 | 2.67E-20 |
Pathways in cancer | 39 | 4.257452 | 1.77E-12 |
Cell cycle | 30 | 8.4032 | 1.78E-17 |
MAPK signaling pathway | 27 | 3.600042 | 2.30E-07 |
Cytokine-cytokine receptor interaction | 24 | 3.297377 | 4.66E-06 |
Focal adhesion | 23 | 4.11424 | 2.30E-07 |
Regulation of actin cytoskeleton | 23 | 3.847576 | 7.25E-07 |
Small cell lung cancer | 20 | 8.4032 | 7.25E-12 |
Purine metabolism | 20 | 4.723367 | 2.30E-07 |
Endocytosis | 20 | 3.864573 | 3.69E-06 |
p53 signaling pathway | 19 | 9.949875 | 1.71E-12 |
Pyrimidine metabolism | 17 | 6.33272 | 3.70E-08 |
Tight junction | 17 | 4.584133 | 3.09E-06 |
Natural killer cell mediated cytotoxicity | 17 | 4.483751 | 3.65E-06 |
Chemokine signaling pathway | 17 | 3.199343 | 0.000168 |
Cell adhesion molecules (CAMs) | 15 | 4.044824 | 4.55E-05 |
Lysosome | 14 | 4.398892 | 3.96E-05 |
Leukocyte transendothelial migration | 14 | 4.25103 | 4.86E-05 |
Axon guidance | 14 | 3.921493 | 0.000105 |
T cell receptor signaling pathway | 13 | 4.349434 | 7.40E-05 |