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Table 1 Expression probes associated with 17q21.31 inversion region in different datasets

From: Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner

  

Whole blood

  
 

Probe ID

t

B (95% CI)

p

LRRC37A4

ILMN_2393693

18.29

0.37 (0.33, 0.41)

1.4 x 10-55

MGC57346

ILMN_1784428

−8.63

−0.19 (−0.24, -0.15)

1.2 x 10-16

PLEKHM1

ILMN_1709549

ns

ns

ns

MAPT

dt

dt

dt

dt

LRRC37A

ILMN_1783673

ns

ns

ns

CRHR1

ILMN_1732426

ns

ns

ns

  

Cerebellum

  
 

Probe ID

t

B (95% CI)

p

LRRC37A4

n/a

n/a

n/a

n/a

MGC57346

n/a

n/a

n/a

n/a

PLEKHM1

ILMN_1709549

4.98

0.18 (0.11, 0.25)

1.9 x 10-6

MAPT

ILMN_1710903

6.01

0.36 (0.24, 0.48)

1.6 x 10-8

LRRC37A

ILMN_1783673

ns

ns

ns

CRHR1

ILMN_1753706

−4.18

−0.09 (−0.13, -0.05)

5.2 x 10-5

  

Frontal Cortex

  
 

Probe ID

t

B (95% CI)

p

LRRC37A4

n/a

n/a

n/a

n/a

MGC57346

n/a

n/a

n/a

n/a

PLEKHM1

ILMN_1709549

ns

ns

ns

MAPT

ILMN_1710903

4.76

0.34 (0.20, 0.48)

4.8 x 10-6

LRRC37A

ILMN_1783673

−7.92

−0.25 (−0.32, -0.19)

7.4 x 10-13

CRHR1

ILMN_1753706

dt

dt

dt

  

Temporal Cortex

  
 

Probe ID

t

B (95% CI)

p

LRRC37A4

n/a

n/a

n/a

n/a

MGC57346

n/a

n/a

n/a

n/a

PLEKHM1

ILMN_1709549

n/a

ns

ns

MAPT

ILMN_1710903

ns

ns

ns

LRRC37A

ILMN_1783673

−9.15

−0.29 (−0.35, -0.23)

6.9 x 10-16

CRHR1

ILMN_1753706

dt

dt

dt

  

Pons

  
 

Probe ID

t

B (95% CI)

p

LRRC37A4

n/a

n/a

n/a

n/a

MGC57346

n/a

n/a

n/a

n/a

PLEKHM1

ILMN_1709549

ns

ns

ns

MAPT

ILMN_1710903

ns

ns

ns

LRRC37A

ILMN_1783673

−6.03

−0.17 (−0.23, -0.12)

1.5 x 10-8

CRHR1

ILMN_1753706

dt

dt

dt

  1. The genes found to be associated to the 17q21.31 inversion haplotypes are listed in the first column with their corresponding probe IDs (Illumina H12.v3 in blood and Illumina H8.v2 in brain). The genes have been tested in two datasets and results of linear regression are given, t, B (with 95% CI) and p-values. The B values indicate the actual change in expression associated with each copy of the H1 allele (0, 1 or 2). The corresponding unadjusted p-values are listed when significant. Not all genes were available or detected in each dataset; n/a = not available on array, dt = did not meet detection threshold in tissue, ns = not significant. All probes for the genes in the 17q21.31 region are listed in Additional file 1: Table S1.
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BMC Genomics

ISSN: 1471-2164

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