Table 2 Established and putative virulence determinants of Y. enterocolitica
Genomic origin | Protein | Function | Sequence similarity |
|---|---|---|---|
Virulence-associated determinants | |||
Plasmid (pYV) | |||
yop | Yops | Anti-phagocytic action | YopM: 75% (protein) |
ysc | Ysc | Deliver of Yops | YscP: 72% (protein) |
yadA | YadA | Attachment, invasion | 97% (protein) |
Chromosome | |||
inv | Invasin | Attachment, invasion | 100% (protein) |
ail | Ail | Attachment, invasion | 96% (protein) |
myfEFABC | Myf fibrillae | Intestinal colonization | 97% (DNA) |
HPI | Yersiniabactin | Dissemination in the host | 98% (DNA) |
ureABC | Urease | Bacterial survival in acidic environments | 100% (protein) |
flhDC | Flagella | Migration and adherence to host cells | 100% (protein) |
Ysa (PZ) | T3SS | Secretion of Ysps proteins | 98% (DNA) |
Yts1 (PZ) | GSP | Dissemination into deep tissues | 99% (DNA) |
Yts2 | GSP | Unclear | 98% (DNA) |
ystA | Enterotoxin | Fluid loss and diarrhea | 100% (protein) |
Putative virulence determinants identified in this study | |||
Chromosome | |||
YE0694 | Putative adhesin | Adherence | 75% (protein) |
YE3700 | Outer membrane protein/ Autotransporter | Adherence and invasion | 23% (protein) |
YE1111 | Fimbrial protein | Adherence | 40% (protein) |