Table 3 KEGG pathway analysis for those genes whose mRNA expression was significantly associated with miRNA expression (p < 0.05)
miRNA | Correlated genes (n = 17208) | SIGNIFICANTLY ENHANCED KEGG PATHWAYS (4 gene threshold) | ||
|---|---|---|---|---|
p < 0.05 | q < 0.2 | KEGG Pathway name | (observe, expected, p-value) | |
miR-15b | 541 | 1 | Focal adhesion | (o = 10; e = 1.8; p = 2.8e-5) |
Regulation of actin cytoskeleton | (o = 10; e = 1.9; p = 4.2e-5) | |||
Long-term potentiation | (o = 5; e = 0.6; p = 6.3e-4) | |||
Pancreatic cancer | (o = 4; e = 0.7; p = 7.1e-3) | |||
Long-term depression | (o = 4; e = 0.7; p = 7.7e-3) | |||
Axon guidance | (o = 4; e = 1.3; p = 4.0e-2) | |||
miR-212 | 858 | 0 | MAPK signaling pathway | (o = 12; e = 3.8; p = 7.1e-4) |
Regulation og actin cytoskeleton | (o = 10; e = 2.8; p = 7.4e-4) | |||
Calcium signaling pathway | (o = 8; e = 2.4; p = 4.5e-3) | |||
Tight junction | (o = 8; e = 1.6; p = 3.2e-4) | |||
miR-34c | 532 | 0 | MAPK signaling pathway | (o = 12; e = 2.7; p = 3.3e-5) |
Jak-STAT signaling pathway | (o = 7; e = 1.5; p = 9.9e-4) | |||
Focal adhesion | (o = 7; e = 1.9; p = 3.6e-3) | |||
Long-term depresion | (o = 4; e = 0.7; p = 8.4e-3) | |||
miR-31 | 586 | 0 | Regulation of actin cytoskeleton | (o = 11; e = 2.1; p = 1.5e-5) |
MAPK signaling pathway | (o = 10; e = 2.9; p = 8.5e-4) | |||
Axon guidance | (o = 9; e = 1.3; p = 1.5e-5) | |||
GnRH signaling pathway | (o = 7; e = 1.0; p = 1.0e-4) | |||
Wnt signaling pathway | (o = 6; e = 1.5; p = 5.5e-3) | |||
miR-301a | 927 | 0 | Focal adhesion | (o = 13; e = 3.1; p = 2.5e-5) |
Regulation of actin cytoskeleton | (o = 11; e = 3.2; p = 6.0e-4) | |||
MAPK signaling pathway | (o = 10; e = 4.4; p = 1.6e-2) | |||
Colorectal cancer | (o = 7; e = 1.4; p = 6.5e-4) | |||
Long-term potentiation | (o = 4; e = 1.1; p = 2.5e-2) | |||