Schematic representation of the proposed indirect HKII / ANT2 co-regulation in glycolytic conditions. In glycolytic conditions, the mitochondrial hexokinase isoform, HK II, generates ATP from cytoplasmic glucose 6-P (G-6P). The ATP4− is then imported into mitochondria by the ANT2 isoform, contributing to the maintenance of the mitochondrial membrane potential (ΔΨm). The HKII gene transcription is induced by the HIF1-alpha protein. CBP/p300, CREB-binding protein; ARNT, aryl hydrocarbon nuclear translocator; HRE, hypoxia response element.