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Table 3 Genes co-regulated with ANT2

From: Computational identification of transcriptionally co-regulated genes, validation with the four ANT isoform genes

Gene, ENSG ID

Encoded protein (EnsEMBL)

Protein function (UniProt)

AURKC

Serine/threonine-protein kinase 13

Organizing microtubules during mitosis and chromosome segregation

105146

 

BTG1

B-cell translocation gene 1 protein

Anti-proliferative protein, associated with the G1 phase of the cell cycle

133639

 

CDKN2AIP

CDKN2A-interacting protein

Activates p53/TP53 by CDKN2A-dependent and independent pathways

168564

 

CEBPB

CCAAT/enhancer-binding protein beta

Transcriptional activator of genes involved in immune responses

172216

 

CKB δ

Creatine kinase B-type

Transfer of phosphate between ATP and various phosphogens

166165

 

COL1A1

Collagen alpha-1(I) chain

Type I collagen is a member of group I collagen

108821

 

DDIT4L*

DNA damage-indu- cible transcript 4

Inhibits cell growth by regulating the TOR signaling pathway

145358

 

DKK1

Dickkopf-related protein 1

Antagonizes Wnt signalling by inhibiting LRP5/6 interaction with Wnt

107984

 

FGL1* δ

Fibrinogen-like protein 1

Hepatocyte mitogenic activity

104760

 

GADD45B

Growth arrest inducible GADD45 β

Regulation of growth - apoptosis, activation of stress-responsive genes

99860

 

GDF15

Growth/differentiation factor 15

Transforming growth factor beta receptor signalling pathway

130513

 

HIF1A

Hypoxia-inducible factor 1-alpha

Master transcriptional regulator of the adaptive response to hypoxia

100644

 

KCNJ8

ATP-sensitive rectifier K+ channel 8

This potassium channel is controlled by G proteins

121361

 

LY96*

Lymphocyte antigen 96

Cooperates with TLR4 in response to bacterial lipopolysaccharide

154589

 

NPPC

C-type natriuretic peptide

Proliferation/differentiation regulation of growth plate chondrocytes

163273

 

RARRES1

RAR responder protein 1

Negative regulation of cell proliferation

118849

 

SMCHD1

Chromosome domain maintenance

ATP binding

101596

 
  1. Several constructed models of the ANT2 promoter region were screened as described in Figure 1 either on the whole chromosome human sequences or the human promoter library (results with an asterisk). Function involved in cell proliferation is shown in bold characters. Genes in bold are shown overexpressed in microarrays ( Additional file 3). δNo correct probe set on Affymetrix chips corresponding to this gene. Gene IDs are with 15 numbers (ex. ENSG00000023228).