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Table 4 Genes co-regulated with ANT4

From: Computational identification of transcriptionally co-regulated genes, validation with the four ANT isoform genes

Gene, ENSG ID

Encoded protein (EnsEMBL)

Protein function (UniProt)

AMDHD2

Acetylglucosamine-6-phosphate deacetylase

N-acetyl-D-glucosamine 6-P + H2O = D-glucosamine 6-P + acetate

162066

 

APEX1*

APEX nuclease (DNA repair enzyme) 1

Repair of apurinic / apyrimidinic sites in testis

100823 §

 

CDK4*

cyclin-dependent kinase 4

Cell cycle G1 phase progression in male reproduction

135446 §

 

CLPB*

Caseinolytic peptidase B protein homolog

Function as a regulatory ATPase and related to protein secretion

162129

 

FIP1L1

Pre-mRNA 3'-end-processing factor FIP1

Contributes to poly(A) site recognition and poly(A) addition

145216

 

FLJ32713 δ

Unknown (TESTI2000756)

Unknown (expressed in testis)

fis §

 

FNDC3A*

Fibronectin type-III domain-containing 3A

Mediates spermatid-Sertoli adhesion during spermatogenesis

102531

 

G6PC2*

Glucose-6-phosphatase 2

Glucose production, expressed in testis

152254

 

G6PC3*

Glucose-6-phosphatase 3

Glucose production in endoplasmic reticulum, expressed in testis

141349

 

KAT5*

K(lysine) acetyltransferase 5

Chromatin remodelling with an abundant spermatid protein

172977 §

 

KLHL12*

Kelch-like protein 12

Ubiquitin-protein E3 ligase complex adapter, highly expressed in testis

117153

 

LAMP1*

lysosomal-associated membrane protein 1

Binds amelogenin, differentially expressed in spermiogenesis

185896 §

 

RPUSD4*

RNA pseudouridylate synthase domain-containing

Unknown, expressed in prostate

165526 §

 

SLC2A4

solute carrier family 2, member 4 (GLUT4)

Facilitated glucose transporter, detected in human testis

181856 §

 

SOHLH1

spermatogenesis and oogenesis specific HLH1

Germ cell-specific, oogenesis regulator and male germ cells

165643 §

 

SUN1

chr. 7 unc-84 homolog A

Nuclear anchorage/migration, expres- sion of meiotic reproductive genes

164828 §

 

TDRD1*

tudor domain containing 1

Essential for spermiogenesis

95627 §

 

THAP8*

O-sialoglycoprotein endopeptidase

Unknown (TESTI2004929)

161277 §

 

TKTL1

transketolase-like 1

Important role in transketolase activity, testis expressed

7350 §

 

TMEM184A

transmembrane protein 184A = Sdmg1

Male-specific expression in embryonic gonads

164855 §

 

UBE2B*

ubiquitin-conjugating enzyme E2B

Post-replicative DNA damage repair in spermatogenesis

119048 §

 
  1. Several constructed models of the ANT4 promoter region were screened as described in Figure 1 either on the full chromosomal human sequences or the human promoter library (results with an asterisk). Function involved in spermatogenesis or in testis or prostate metabolism is shown in bold characters. Genes in bold are shown overexpressed in microarrays ( Additional file 3). §Genes identified in the previous ModelInspector / GeneProm analysis [2]. δNo correct probe set on Affymetrix chips corresponding to this gene.
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BMC Genomics

ISSN: 1471-2164

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