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Table 2 Agonistically linked traits

From: Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases

Disease

Abbr.

Agonistically Linked Traits (Loci)

#

CROHN DISEASE

CD

UC (1p31, 1q32, 3p21, 5p13, 9p24, 9q32, 9q34, 10q24, 21q21, 21q22); IBD (1p31, 9q32, 10q22, 16q12, 20q13, 22q12); CeD (2q12, 18p11, 22q11); LEP (9q32, 13q14); MG (22q12); T1D (1q32, 18p11); SC (3p21); OVARIAN NEOPLASMS (8q24); AS (1p31); LL (2q37); HTG (2p23); AA (11q13); MS (10p15); AD (11q13)

14

ARTHRITIS, RHEUMATOID

RA

CeD (1p36, 4q27, 6q23); SLE (2q32, 7q32, 8p23); T1D (2q33, 4p15, 21q22); BLC (7q32); SS (7q32); FL (6p21); UC (6q23); LBL (6p21); SCHIZOPHRENIA (6p21); VIT (21q22)

10

CELIAC DISEASE

CeD

CD (2q12, 18p11, 22q11); RA (1p36, 4q27, 6q23); UC (2p16, 6q23); T1D (18p11); BLC (7p14); VIT (3q28); HYP (12q24); SLE (6p21); MG (6p21)

9

COLITIS, ULCERATIVE

UC

CD (1p31, 1q32, 3p21, 5p13, 9p24, 9q32, 9q34, 10q24, 21q21, 21q22); CeD (2p16, 6q23); AS (1p31, 2q11); IBD (1p31, 21q22); SC (3p21); PS (1p31); RA (6q23); T1D (1q32); SLE (7q32)

9

CORONARY DISEASE

COR

MCI (1p13, 1p32, 1q41, 2q33, 6p24, 9p21, 10q11, 19p13, 21q22); CAD (1p13, 3q22, 9p21); ICA (10q24); PD (10q24); AAA (9p21); HYP (10q24); HTG (11q23)

7

LUPUS ERYTHEMATOSUS, SYSTEMIC

SLE

RA (2q32, 7q32, 8p23); SS (2q32, 7q32); LN (6p21); BLC (7q32); MG (6p21); UC (7q32); CeD (6p21)

7

DIABETES MELLITUS, TYPE 1

T1D

RA (2q33, 4p15, 21q22); CD (2q33, 4p15, 21q22); CeD (18p11); AA (12q13); VIT (21q22); UC (1q32)

6

HYPERTENSION

HYP

ICA (10q24); PD (10q24); COR (10q24); KIDNEY FAILURE, CHRONIC (16p12); CeD (12q24)

5

INFLAMMATORY BOWEL DISEASES

IBD

CD (1p31, 9q32, 10q22, 16q12, 20q13, 22q12); LEP (9q32); UC (1p31, 21q22); MG (22q12); AS (1p31)

5

LIVER CIRRHOSIS, BILIARY

BLC

RA (7q32); SLE (7q32); SS (7q32); MS (12p13); CeD (7p14)

5

CORONARY ARTERY DISEASE

CAD

COR (1p13, 3q22, 9p21); MCI (1p13, 9p21); AAA (9p21); T2D (2q36)

4

GLOMERULONEPHRITIS, MEMBRANOUS

MG

IBD (22q12); CD (22q12); SLE (6p21); CeD (6p21)

4

AORTIC ANEURYSM, ABDOMINAL

AAA

COR (9p21); CAD (9p21); MCI (9p21)

3

INTRACRANIAL ANEURYSM

ICA

PD (10q24); HYP (10q24); COR (10q24)

3

LUNG NEOPLASMS

LN

SLE (6p21); COPD (15q25); PVD (15q25)

3

LYMPHOMA, FOLLICULAR

FL

LBL (11q24); RA (6p21); LL (6p21)

3

MYOCARDIAL INFARCTION

MCI

COR (1p13, 1p32, 1q41, 2q33, 6p24, 9p21, 10q11, 19p13, 21q22); CAD (1p13, 9p21); AAA (9p21)

3

PARKINSON DISEASE

PD

HYP (10q24); COR (10q24); ICA (10q24)

3

SCLERODERMA, SYSTEMIC

SS

SLE (2q32, 7q32); RA (7q32); BLC (7q32)

3

SPONDYLITIS, ANKYLOSING

AS

UC (1p31, 2q11); IBD (1p31); CD (1p31)

3

VITILIGO

VIT

CeD (3q28); RA (21q22); T1D (21q22)

3

ALOPECIA AREATA

AA

T1D (12q13); CD (11q13)

2

CHOLANGITIS, SCLEROSING

SC

UC (3q21); CD (3q21)

2

DERMATITIS, ATOPIC

AD

GLIOMA (20q13); CD (11q13)

2

DIABETES MELLITUS, TYPE 2

T2D

OBESITY (16q12); CAD (2q36)

2

HEAD AND NECK NEOPLASMS

HNN

GASTROINTESTINAL NEOPLASMS (10q23); ALCOHOLISM (12q24)

2

HYPERTRIGLYCERIDEMIA

HTG

CD (2p23); COR (11q23)

2

LEPROSY

LEP

CD (9q32, 13q14); IBD (9q32)

2

LEUKEMIA, LYMPHOID

LL

CD (2q27); FL (11q24)

2

LYMPHOMA, LARGE B-CELL, DIFFUSE

LBL

FL (6q21); RA (6q21)

2

MULTIPLE SCLEROSIS

MS

CD (10p15); BLC (12p13)

2

PERIPHERAL VASCULAR DISEASES

PVD

COPD (15q25); LN (15q25)

2

PROSTATIC NEOPLASMS

PRN

COLORECTAL NEOPLASMS (8q24); ENDOMETRIAL NEOPLASMS (17q12)

2

PSORIASIS

PS

UC (1p31); ARTHRITIS, PSORIATIC (6q21)

2

PULMONARY DISEASE, CHRONIC OBSTRUCTIVE

COPD

LN (15q25); PVD (15q25)

2

  1. Listed are diseases that share agonistic associations with at least two traits. In the first column the considered disease is given. The second column specifies the abbreviation of the disorder in the first column. The third column contains the disease abbreviations (as defined in column two) of traits which have an agonistic link to the disorder in column one, followed by the chromosomal location of the agonistically associated variant(s) in parentheses. Here, the full MeSH term is given for traits for which no abbreviation was defined. The last column lists the count of traits agonistically linked to the disorder in column one. For the complete list of agonistically linked traits and more details see Additional file2: Table S1.