Figure 2

Spatial genomic organization of LXR binding locations in relation to T09 target genes. The 202 LXR locations of the high stringency peak set (Figure 1A) and the 1713 T09-regulated genes with adjusted P < 0.01 in 22 + X human chromosomes are visualized. A 1 Mb sliding window was used for the density graphs. These were further segmented, in order to detect chromosomal regions enriching LXR binding locations. One hundred twelve genomic regions were identified as hotspots for LXR actions, of which those with ≥ 2 peaks and ≥ 3 regulated genes are highlighted in red.