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Table 3 Enrichment analysis of high confidence LXR target genes

From: Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

Term Count % P FE FDR
translation 16 6.56 9.14E-05 3.34 0.15
lipid biosynthetic process 15 6.15 2.48E-04 3.21 0.41
cellular response to stress 20 8.20 5.40E-04 2.44 0.89
RNA splicing 13 5.33 8.58E-04 3.16 1.41
response to virus 8 3.28 1.00E-03 5.07 1.64
positive regulation of gene-specific transcription 7 2.87 1.59E-03 5.55 2.60
RNA splicing, via trans-esterification reactions 9 3.69 1.68E-03 4.06 2.75
nuclear mRNA splicing, via spliceosome 9 3.69 1.68E-03 4.06 2.75
RNA splicing, via trans-esterification reactions with bulged adenosine as nucleophile 9 3.69 1.68E-03 4.06 2.75
RNA processing 18 7.38 2.41E-03 2.27 3.90
negative regulation of cholesterol storage 3 1.23 2.98E-03 34.51 4.82
  1. The analysis was performed using the DAVID tool [37] for the specific set of LXR target genes with P < 0.001 for differential expression. GO biological process terms with FDR < 5% are shown. Columns indicate the GO-term, its count and percentage in the target gene list, as well as the P-value, FE and FDR for the enrichment.