Figure 3

Circos plot depicting copy number in the genome. Outer ideogram runs clockwise from chromosome 1 to chromosome X with labels in Mb of physical distance. The data are represented in several tracks. The innermost track is a heat map representing the proportion of variants showing LOH in 5 MB bins for the 130 metastatic sample. The next innermost track shows the LOH results for the 133 metastatic sample. The data tracks depict relative copy number for the 130 met sample (in red) and the 133 met sample (in black). Regions that show large copy number differences between the two metastatic samples are highlighted in light green. Proceeding outward are two more heatmap LOH tracks for sample 14 met and then for sample 98 met. Finally, relative copy number profiles for samples 14 (in black) and 98 (in red) are shown; again, light green highlights regions of significant copy number change. For all heatmap tracks, blue represents no LOH in the region while red represents nearly all SNVs in the region showing LOH.