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Table 3 Functional Annotation Enrichment analysis of statistically-significant over-expressed genes in European eel silver males from the river Tiber site (N = 8) in comparison with silver males from the lake Bolsena site (N = 7). FE = Fold Enrichment

From: Surviving in a toxic world: transcriptomics and gene expression profiling in response to environmental pollution in the critically endangered European eel

Category

Term

Count

P value

FE

KEGG_PATHWAY

dre00052:Galactose metabolism

4

0.004

11.5

 

dre00520:Amino sugar and nucleotide sugar metabolism

5

0.004

7.2

 

dre00591:Linoleic acid metabolism

3

0.010

17.3

 

dre00040:Pentose and glucuronate interconversions

3

0.016

13.8

 

dre00511:Other glycan degradation

3

0.024

11.5

 

dre00500:Starch and sucrose metabolism

3

0.042

8.7

 

dre00980:Metabolism of xenobiotics by cytochrome P450

3

0.042

8.7

INTERPRO

IPR002401:Cytochrome P450, E-class, group I

4

0.007

9.5

 

IPR017973:Cytochrome P450, C-terminal region

4

0.009

8.8

 

IPR017972:Cytochrome P450, conserved site

4

0.009

8.8

 

IPR001128:Cytochrome P450

4

0.011

8.1

 

IPR012335:Thioredoxin fold

5

0.041

3.7

SP_PIR_KEYWORDS

heme

5

0.010

5.6

 

monooxygenase

4

0.010

8.4

 

oxidoreductase

8

0.023

2.7

GOTERM_BP

GO:0055114 ~ oxidation reduction

11

0.005

2.7

 

GO:0019882 ~ antigen processing and presentation

4

0.007

9.6

 

GO:0006955 ~ immune response

4

0.042

5.0

GOTERM_MF

GO:0009055 ~ electron carrier activity

7

0.013

3.5

 

GO:0020037 ~ heme binding

5

0.025

4.3

 

GO:0043167 ~ ion binding

27

0.037

1.4

 

GO:0043169 ~ cation binding

27

0.037

1.4

 

GO:0046906 ~ tetrapyrrole binding

5

0.039

3.8