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Table 2 Summary of DAVID Gene Ontology analysis of genes near LRH-1 binding regions

From: Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR

Category

Term

GO Term

Count

%

P value

Benjamini

FDR

GOTERM_BP

GO:0044255

Cellular lipid metabolic process

25

9.73

1.07E-06

0.00552

0.002

GOTERM_BP

GO:0006629

Lipid metabolic process

26

10.12

3.88E-06

0.01003

0.0074

GOTERM_BP

GO:0008152

metabolic process

141

54.86

1.82E-05

0.031

0.0348

GOTERM_BP

GO:0008202

Steroid metabolic process

10

3.89

2.95E-04

0.31791

0.5618

GOTERM_BP

GO:0044237

Cellular metabolic process

125

48.64

3.00E-04

0.26791

0.5722

GOTERM_BP

GO:0008203

Cholesterol Metabolic Processes

7

2.72

3.97E-04

0.29075

0.7557

GOTERM_BP

GO:0016125

Sterol metabolic process

7

2.72

6.63E-04

0.3885

1.259

GOTERM_BP

GO:0044238

Primary metabolic process

123

47.86

8.15E-04

0.41083

1.5454

GOTERM_BP

GO:0008610

Lipid biosynthetic process

12

4.67

8.48E-04

0.38705

1.608

GOTERM_BP

GO:0009058

Biosynthetic process

33

12.84

0.001103

0.43623

2.0869

GOTERM_BP

GO:0044248

Cellular catabolic process

16

6.23

0.002877

0.74332

5.356

GOTERM_BP

GO:0032787

Monocarboxylic acid metabolic process

10

3.89

0.004361

0.84904

8.0104

GOTERM_BP

GO:0006066

Alcohol metabolic process

11

4.28

0.005747

0.89995

10.428

GOTERM_BP

GO:0006631

Fatty acid metabolic process

8

3.11

0.008909

0.86381

15.716

GOTERM_BP

GO:0019752

Carboxylic acid metabolic process

15

5.84

0.010269

0.97193

17.899

GOTERM_BP

GO:0006082

Organic acid metabolic process

15

5.84

0.010587

0.96837

18.4

  1. 367 genes close to LRH-1 peaks that overlap with FXR peaks were used to group into enriched functionally important categories using the PANTHER "Biological Process" term