Table 2 Regulation of key metabolic pathways in guinea pig lungs infected with M. tuberculosis
Pathway | Up | Down |
|---|---|---|
Oxidative Phosphorylation | NDUFA12, NDUFV1, UQCRC2, SDHB, NDUFAB1, ATP5C1, PPA1, ATP6V0E1, ATP5J, NDUFB8, ATP5A1, NDUFA7, COX5A, LHPP, UQCRC1, ATP5G3, NDUFA11, ATP5J2, NDUFV3, NDUFV2, NDUFS6, NDUFS8, NDUFS3, ATP6V1D, COX5B, COX6A2, COX4I1, ATP6V1F, ATP6V0D1, COX7A2L, ATP6V0C, ATP6V1E1, ATP6V0B, ATP6V1B2, NDUFB4, NDUFB2, NDUFA3, COX17 | ATP5O, ATP5F1, ATP12A, NDUFB5, NDUFB7, NDUFA4 |
Glycolysis/Gluconeogenesis | LDHA, ENO1, HK1, ADH5, TPI1, GAPDH, ADH1A, AKR1A1, ALDOA, PGK2, ENO3, GPI | ALDOC, DLAT, PFKL |
TCA cycle | FH, SDHB, PC, MDH2, IDH1, ACO2, SUCLG1 | DLAT |
Lipid, Glycerolipid and Glycerophospholipid metabolism | ABHD2, ABHD8, ACSL5, ADH1A, ADH5, AGPAT2, AKR1A1, CPT2, CEPT1, CYP27A1, CYP2B18A, CYP26B1, DGKA, FDPS, GCDH, HADHA, HADHB, LPL, PLA2G2A, PGS1 | AGPAT1, AGPAT3, ACSL1, CPT1B, CYP2F1, CYP2A13, CYP1A2, CYP11A1, CYP2D40, PLD2, PPAP2A, PLA2G2C, PLA2G5, PAFAH1B1, PNPLA3, PTDSS2, LPGAT1 |
Purine and Pyrimidine metabolism | ADSS, NT5C2, NPR2, AK2, XDH, ADCY4, POLR2E, HPRT1, PRP, DPYD, TXNRD2, NT5C2, CAD | AK1, DCTD, POLA1, POLR2F, POLR2K, PRPS1L1, GUK1, PDE6G, PDE6A, POLR3GL, ENPP1, ZNRD1, PRUNE, TYMS, TK1 |
Amino acid metabolism | GLUL, GCDH, HADHA, HADHB, PLOD3, TMLHE, SETD1A, SETD8, HSD17B10, IVD, LDHA, MIF, PRDX6 | ALDH4A1, ALDH6A1, ASS1, AMT, AGXT, AGMAT, ABAT, AHCYL1, CYP1A2, CKB, DNMT1, DBT, DDC, GLS, GLUD1, GLDC, GNMT, HMGCS1, NOS1, MAT2A, ODC1, WHSC1L1, SUV420H2, SUV420H1 |