Table 3 Regulation of key signaling pathways in guinea pig lungs infected with M. tuberculosis
Pathway | Up | Down |
|---|---|---|
MAPK | MRAS, MAPK7, RAC1, TGFB1, MAPKAPK5, MAPKAPK2, FGFR3, IL1B, PLA2G2A, RAC2, RAP1B, SOS2, MAPK8IP3, RRAS, HSPB1, CACNA1E, ARRB2, MAP2K2, FGF17, STK4, SRF, PAK2 | MEF2C, CACNB2, CACNB4, TAOK3, CACNG4, DUSP9, FGFR4, PPP5C, FGFR2, FGFR1, RAP1A, CACNA1C, FOS, TNF, RPS6KA1, TGFB3, PPM1A, FGF19, ATF4, AKT3, CRKL, MAPK11, FGF8, MAPK1, FGF2, TP53, PPP3CB, MAPK8IP2, FGF12, FGF10, MAP3K4, PLA2G2C, PLA2G5, PRKACG, PRKACA, CHUK, PTPRR, RASA1, CACNA1S, BRAF, MAP2K6, MAP2K1, DUSP2, DUSP4, RASGRP2 |
Wnt | RAC1, CUL1, CSNK2A2, PPP2R1A, RAC2, CSNK1A1, PPP2CA, RHOA, PSEN1 | PRICKLE1, CSNK1E, LRP5, PLCB3, EP300, TBL1XR1, CTBP1, WNT3, CAMK2G, CAMK2A, CCND1, NKD2, SMAD4, SMAD2, PPP2R5D, TP53, PPP3CB, CSNK2A1, CTNNB1, PRKACG, PRKACA, CAMK2D, LEF1, WNT10A, FBXW11, BTRC, FZD9, FZD3, TCF7L2 |
Calcium | VDAC1, ERBB2, ATP2A1, GNAQ, TNNC1, CACNA1E, P2RX2, ADCY4, SLC25A6 | PLCB3, ADRA1B, PHKG2, CACNA1C, ADORA2A, CAMK2G, CAMK2A, GNAS, PLN, HTR6, NOS1, RYR1, VDAC2, PPP3CB, SLC8A1, CYSLTR1, P2RX1, CALM2, ATP2B4, ATP2A3, PRKACG, PRKACA, CAMK2D, LTB4R2, CACNA1S, ADRB2, PLCG1 |