Table 4 Regulation of key immune response related genes in guinea pig lungs infected with M. tuberculosis

Chemokine signaling pathway

GNB4, RAC1, IL8, GNG5, HCK, RAC2, FOXO3, RAP1B, SOS2, ADRBK1, NCF1, GNAI2, CCL27, VAV3, RHOA, ADCY4, ARRB2, NFKBIB

GNB1, PLCB3, CCL5, CXCL9, RAP1A, CXCR3, GNG8, GNG2, CCL21, AKT3, CRKL, MAPK1, PRKACG, PRKACA, CHUK, CCL11, BRAF, MAP2K1, RASGRP2

Cell adhesion molecules (CAMs)

HLA-DQB1, ITGB7, HLA-A, HLA-B, HLA-B, HLA-DMA, NRXN2, HLA-DPA1, HLA-DRB1, HLA-DRB1, ALCAM, CLDN18, CLDN14

MPZL1, HLA-E, HLA-F, CADM3, CADM1, CD34, CD8A, CD99, CDH3, CLDN4, CLDN6, NCAM1, GLG1, NLGN2, ITGB2, ITGB8, ITGA9, CNTNAP1, SIGLEC1

Cytokine-cytokine receptor interaction

IL1, RAP, IL8, TGFB1, IL1B, CSF1R, IL23A, BMP8A, CCL27, BMP4, BMPR2

GHR, CCL5, CD70, CXCL9, KIT, CD27, CXCR3, TNFα, IL2RG, CNTFR, BMPR1A, IL23R, CCL21, TGFB3, FLT4, BMP5, IFNGR2, LTA, IL9, CCL11, TNFSF10, ACVR2A

Leukocyte trans-endothelial migration

RAC1, CYBA, CYBB, RAC2, RAP1B, ACTG1, NCF1, GNAI2, EZR, ACTN4, VAV3, RHOA, PTPN11, CLDN18, CLDN14, ACTB

RAP1A, CD99, RHOH, THY1, MAPK11, CTNNB1, CLDN4, CLDN6, ITGB2, MLLT4, PLCG1

Natural killer cell mediated cytotoxicity

RAC1, ARAF, HLA-A, HLA-B, RAC2, SOS2, VAV3, LAT, FCER1G, PTPN11, MAP2K2, PTPN6

TYROBP, HLA-E, HLA-F, TNF, IFNGR2, MAPK1, PPP3CB, GZMB, ITGB2, TNFSF10, BRAF, MAP2K1, PLCG1

T cell receptor signaling pathway

SOS2, GRAP2, VAV3, LAT, RHOA, NFKBIB, MAP2K2, PTPN6, PAK2

CD8A, FOS, TNF, NCK1, AKT3, MAPK11, MAPK1, PPP3CB, CHUK, MAP2K1, PLCG1

B cell receptor signaling pathway

RAC1, RAC2, SOS2, CD81, VAV3, LILRB3, NFKBIB, MAP2K2, PTPN6, CR2

FOS, AKT3, MAPK1, PPP3CB, CHUK, MAP2K1

Antigen processing and presentation

HLA-DQB1, HLA-A, HLA-B, HLA-B, CD74, HLA-DMA, HLA-DPA1, HLA-DRB1, HLA-DRB1, HSP90AB1, CTSB, CTSS, HSP90AA1

HLA-E, HLA-F, CD8A, TNF, TAPBP, HSPA5, PSME2

Complement and coagulation cascades

C4A, C3, C1S, SERPING1, CR2

CD55, MASP2, KNG1, SERPINC1, F8, C9, C6, C3AR1, C5AR1