Hierarchical clustering of significant biological concepts from directional LRpath tests. The data from 10 different cancer versus normal CpG methylation studies were subjected to directional LRpath analysis and then clustered using criteria indicated in the figure. The clustering of LRpath results suggests that similar pathways across multiple cancers are affected by differential DNA methylation. The majority of the enriched hypomethylated concepts were immune-response related. Concepts related to early development are enriched with genes harbouring hypermethylation.