Figure 5

The percentage of PRC2 target vs. non-target genes harbouring significant (p-value<0.05) differential methylation. The significant differentially methylated genes from a select few developmental concepts including dermal, embryo, and neural development were subjected to further analysis with respect to PRC2 targets and the presence of CpG islands. As reported, a higher proportion of PRC2 target genes was differentially methylated in multiple tumor types. Interestingly, none of the PRC2 target genes involved in dermal development were differentially methylated in multiple myeloma.