Figure 6

Hierarchical clustering of significant biological concepts from non-directional LRpath tests. The data from 10 different cancer studies were subjected to non-directional LRpath analysis and then clustered using criteria indicated in the figure. The clustering of LRpath results suggests that similar pathways across multiple cancers are consistently depleted or enriched by the differentially methylated genes. Concepts such as DNA repair and cell cycle activity, which play a crucial role in cancer development and progression, are depleted in differentially methylated genes (Criteria: At least one study with p-value < 0.00001, N=661 genes).