Figure 3From: Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditionsSchematic representation of the activated signals corresponding to periportal-like HCC (μFB cultures) and perivenous-like HCC (PD cultures) as the result of loss or over-activation of β-catenin, respectively. Genetic pathways are significantly induced under loss of β-catenin, leading to periportal-like phenotype (with production of energy by oxidative phosphorylation) in μFB hepatocytes. β-catenin-dependent signals are significantly enriched in the perivenous-like hepatocytes of PD cultures.Back to article page