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Table 9 Description of the top six canonical pathways significantly modulated in liver tissue when comparing H to L animals

From: Liver transcriptome profile in pigs with extreme phenotypes of intramuscular fatty acid composition

Ingenuity canonical pathways

Genes

LPS/IL-1 Mediated Inhibition of RXR Function

ABCG8,CYP2C9,CYP7A1,CYP2C19, CYP4A11,GSTO1

Arachidonic Acid Metabolism

ALOX15,CYP2C9,CYP2C19,CYP4A11

Fatty Acid Metabolism

CYP2C9,CYP2C19,SDS,CYP4A11

PXR/RXR Activation

CYP2C9,CYP7A1,CYP2C19

Linoleic Acid Metabolism

ALOX15,CYP2C9,CYP2C19

FXR/RXR Activation

ABCG8,APOB,CYP7A1

  1. Statistical significance of pathway modulation was calculated via a right-tailed Fisher’s Exact test in Ingenuity Pathway analysis and represented as –log (P value): -log values exceeding 1.30 were significant FDR <0.05.
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BMC Genomics

ISSN: 1471-2164

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