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Table 3 Enriched Pathway Maps (A) and Process Networks (B) for genes differentially regulated by BaP

From: Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics

Rank

A. Pathway Maps

pValue

1

Apoptosis and survival_ER stress response pathway

6.5E-06

2

NRF2 regulation of oxidative stress response

7.7E-06

3

Role of alpha-6/beta-4 integrins in carcinoma progression

1.5E-05

4

Mechanisms of CFTR activation by S-nitrosoglutathione

1.8E-05

5

Immune response_IL-12 signaling pathway

1.8E-05

6

Oxidative stress_Role of ASK1 under oxidative stress

1.9E-05

7

Development_TGF-beta-dependent induction of EMT via MAPK

2.1E-05

8

Development_Glucocorticoid receptor signaling

2.4E-05

9

Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling

2.4E-05

10

Immune response_IL-7 signaling in T lymphocytes

4.1E-05

 

B. Networks

 

1

Protein folding_Response to unfolded proteins

2.9E-08

2

Cell adhesion_Platelet-endothelium-leucocyte interactions

9.0E-06

3

Protein folding_ER and cytoplasm

3.8E-05

4

Development_Blood vessel morphogenesis

4.7E-05

5

Reproduction_Spermatogenesis, motility and copulation

5.1E-05

6

Cell adhesion_Cell-matrix interactions

5.2E-05

7

Signal transduction_ESR1-nuclear pathway

6.3E-05

8

Development_Regulation of angiogenesis

2.8E-04

9

Proteolysis_Connective tissue degradation

5.3E-04

10

Signal transduction_NOTCH signaling

6.0E-04