Table 1 Differentially expressed miRNAs in infarcted tissue compared to corresponding remote myocardium, their classification (from miRBase) and prediction of targeting SERCA2 (PicTar, TargetScan, miRanda, mirTarget2)
miRNA | average log2 | average log2* | predicted | miRNA Gene family | Clustered (chr: miR; location) |
|---|---|---|---|---|---|
let-7b | 0.04 | −0.32 | Yes | let-7 | 22: let-7a-3, miR-4763; intronic |
let-7c | −0.87 | −0.88 | Yes | let-7 | 21: miR-99a; intronic |
let-7d | −1.34 | −1.33 | Yes | let-7 | 9: let-7a-1, let-7f-1; intronic |
let-7g | −1.50 | −1.67 | Yes | let-7 | 3: as single gene; intronic |
miR-1 | −3.28 | −1.89 | No | miR-1 | 18: miR-133a-1; intronic |
20: miR-133a-2; intronic | |||||
miR-122 | 3.28 | ND | No | miR-122 | 18: miR-3591; intergenic |
miR-125a-5p | −1.53 | −1.46 | No | miR-125 | 19: let-7e, miR-99b; intronic |
miR-125b | −0.44 | −0.47 | No | miR-125 | 11: as single gene; intronic |
miR-126 | −2.00 | −0.50 | No | miR-126 | 9: as single gene; intronic |
miR-133a | −1.52 | ND | No | miR-133 | 18: miR-1-2; intronic |
20: miR-1-1; intronic | |||||
miR-133b | −1.53 | ND | No | miR-133 | 6: miR-206; intronic |
miR-140-3p | 0.32 | ND | No | miR-140 | 16: as single gene; intronic |
miR-143 | −0.26 | ND | No | miR-143 | 5: miR-145; intergenic |
miR-145 | −0.79 | ND | No | miR-145 | 5: miR-143; intergenic |
miR-150 | −1.63 | −1.60 | No | miR-150 | 19: as single gene; intergenic |
miR-16 | −0.03 | ND | No | miR-15 | 13: miR-15a; intronic |
3: miR-15a; intronic | |||||
miR-195 | −0.51 | −1.37 | Yes | miR-15 | 17: miR-497; intronic |
miR-197 | −0.57 | ND | No | miR-197 | 1: as single gene; intergenic |
miR-199a-3p | 0.39 | ND | No | miR-199 | 19: as single gene; intronic |
1: miR-199a-2, miR-3120, miR-214; intronic | |||||
miR-19b | −2.36 | ND | Yes | miR-19 | 13: miR-17, miR-18a, miR-19a, miR-20a, miR-92a-1; intergenic |
X: miR-106a, miR-18b, miR-20b, miR-92a-2, miR-363; intergenic | |||||
miR-21 | −0.05 | ND | No | miR-21 | 17: as single gene; intergenic |
miR-23a | −1.71 | −0.20 | No | miR-23 | 19: miR-27a, miR-24-2; intergenic |
miR-26a | −1.50 | −0.54 | No | miR-26 | 3: as single gene; intronic |
12: as single gene; intronic | |||||
miR-27a | −1.97 | −1.60 | No | miR-27 | 19: miR-23a, miR-24-2; intergenic |
miR-27b | −2.18 | −1.19 | No | miR-27 | 9: miR-23b, miR-24-1, miR-3074; intronic |
miR-29a | −1.40 | ND | Yes | miR-29 | 7: miR-29b-1; intergenic |
miR-29c | −2.28 | ND | No | miR-29 | 1: miR-29b-2; intergenic |
miR-30a | −2.23 | −1.25 | Yes | miR-30 | 6: as single gene; intronic |
miR-30b | −3.03 | −2.01 | Yes | miR-30 | 8: miR-30d; intergenic |
miR-30c | −2.70 | −2.08 | Yes | miR-30 | 1: miR-30e; intronic |
6: as single gene; intronic | |||||
miR-30d | −1.31 | ND | Yes | miR-30 | 8: miR-30b; intergenic |
miR-30e | −2.71 | ND | Yes | miR-30 | 1: miR-30c-1; intronic |
miR-320a | 2.37 | 0.98 | No | miR-320 | 8: as single gene; intergenic |
miR-320b | 2.24 | 0.98 | No | miR-320 | 1: two copies as single gene; one intronic |
and one intergenic | |||||
miR-320c | 2.27 | 0.98 | No | miR-320 | 18: two copies as single gene; intronic |
miR-320d | 2.13 | 0.98 | No | miR-320 | 13: as single gene; intergenic |
X: as single gene; intergenic | |||||
miR-378 | −1.66 | ND | No | miR-378 | 5. as single gene; intronic |
miR-483-5p | 2.92 | ND | No | miR-483 | 11: as single gene; intronic |
miR-499-5p | −2.94 | −3.36 | Yes | miR-499 | 20: miR-499a; intronic |
miR-574-3p | 2.25 | 2.46 | Yes | miR-574 | 4: as single gene; intronic |
miR-574-5p | 2.17 | 3.18 | No | miR-574 | |
miR-98 | −1.76 | −3.10 | Yes | let-7 | X: let-7f; intronic |