Hepatitis B viral core protein disrupts human host gene expression by binding to promoter regions

BMC Genomics

Table 1 Clinical characteristics of study participants and their corresponding biological samples

Number		Sex	Age	Disease**	HBV DNA (copies/mL)	Tissue weight (mg)
Pool*	Samples	Sex	Age	Disease**	HBV DNA (copies/mL)	Sample	Pool
1	1	male	30	CHB	4.5 × 10⁵	16.8	42.1
	2	male	27	CHB	5.7 × 10⁶	16.0
	3	male	31	CHB	4.2 × 10⁶	9.3
2	4	male	21	CHB	3 × 10⁵	17.0	43.6
	5	male	34	CHB	7.5 × 10⁵	12.1
	6	male	25	CHB	3.2 × 10⁶	14.5
3	7	male	40	CHB	3 × 10⁴	14.3	42.1
	8	male	39	CHB	8.3 × 10⁵	14.8
	9	male	35	CHB	1.34 × 10⁶	13.0
4	10	female	43	CHB	3.6 × 10⁵	10.9	48.6
	11	female	45	CHB	3.7 × 10⁷	17.8
	12	female	40	CHB	6.9 × 10⁷	9.7
	13	female	41	CHB	4.2 × 10⁶	10.2
5	14	male	31	control	undetected	81.0	176.0
	15	male	30	control	undetected	50.0
	16	male	25	control	undetected	45.0

* Liver biopsy samples from three to four individuals were pooled into a single specimen for ChIP-on-chip and ChIP-qPCR analyses.
** CHB, chronic hepatitis B. The serum HBV markers used for diagnosis were: HBsAg(+), HBsAb(−), HBeAg(+), HBeAb(−), and anti-HBc(+). Healthy controls were confirmed as: HBsAg(−), HBsAb(−), HBeAg(−), HBeAb(−), and anti-HBc(−).

ISSN: 1471-2164