Table 2 The genes whose expression time-courses differ between all the lineages
Affymetrix probe ID | Gene symbol | Functional annotation* | Known characteristics in CD4+ T helper cells |
|---|---|---|---|
203881_s_at | DMD(+) | other | NR |
205027_s_at | MAP3K8(+) | kinase | required for proper IFNg production [27] |
228055_at | NAPSB(+) | unknown | NR |
210354_at | IFNG(+) | cytokine | positive regulation on T cell proliferation, tyrosine phosphorylation of STAT1 and production of IL-12 [59] |
200907_s_at | PALLD(+) | other | NR |
222838_at | SLAMF7(+) | other | expression upregulated in Th1 cells[16] |
237322_at | MIAT(+) | other | NR |
1555486_a_at | PRR5L(+) | other | NR |
209369_at | ANXA3(+) | enzyme | expression upregulated in Th1 cells [15] |
230109_at | PDE7B(-) | enzyme | expression upregulated in Th2 cells [17] |
205933_at | SETBP1(-) | other | expression upregulated in Th2 cells [17] |
216252_x_at | FAS(+) | transmembrane receptor | expression regulated by IFNg, important for T cell activation [60, 61] |
219073_s_at | OSBPL10(+) | other | NR |
221271_at | IL21(<2) | cytokine | important for Th17 and follicular Th cell differentiation, increases activation of STAT3 [62–64] |
223475_at | CRISPLD1(+) | other | expression upregulated in Th1 cells [16] |
206999_at | IL12RB2(+) | transmembrane receptor | expression regulated by IFNg, plays a central role in Th1 differentiation [15, 65] |
200878_at | EPAS1(+) | transcription regulator | expression regulated by STAT6 in Th2 cells [17] |
206974_at | CXCR6(+) | G-protein coupled receptor | |
206637_at | P2RY14(+) | G-protein coupled 1receptor | NR |
212062_at | ATP9A(+) | transporter | NR |
210029_at | IDO1(+) | enzyme | NR |
236519_at | C9orf135(-) | other | expression upregulated in Th2 cells [17] |
214038_at | CCL8(+) | cytokine | selectively expressed on Th2 cells, important for trafficking of Th2 cells, required for allergic immune response by Th2 cells [68] |
229764_at | TPRG1(-) | other | expression upregulated in Th2 cells [17] |
231192_at | LPAR3(+) | G-protein coupled receptor | NR |
202421_at | IGSF3(-) | other | expression upregulated in Th2 cells [17] |
221111_at | IL26(<2) | cytokine | expressed on human Th1 cells, increases activation if human STAT1 and STAT3 [69, 70] |
227006_at | PPP1R14A(-) | other | expression upregulated in Th2 cells [17] |
1555785_a_at | XRN1(+) | enzyme | NR |
230110_at | MCOLN2(+) | ion channel | expression upregulated in Th1 cells [16] |
222746_s_at | BSPRY(+) | other | NR |
220684_at | TBX21(+) | transcription regulator | expression up-regulated by IL-12, regulates the production of Th1 hallmark cytokine IFNg [71] |
220603_s_at | MCTP2(+) | other | NR |
210839_s_at | ENPP2(+) | enzyme | used in homing to secondary lymphoid organs [72] |
210164_at | GZMB(+) | peptidase | important for TCR-induced cell death in Th2 but not Th1 cells [73] |
206126_at | CXCR5(+) | G-protein coupled receptor | Il-4 increases expression of CXCR5, important for homing and sensitivity of T cells [74, 75] |
208121_s_at | PTPRO(+) | phosphatase | NR |