Figure 1

Overview of the microarray results. The data is separated according to chromosomal mapping: Autosomes (A), X-chromosome (X) and Y-chromosome (Y). On the x-axis: mean female/male log₂ fold-changes; negative values represent male-bias and positive values represent female-bias. On the y-axis: -log₁₀ p-values (two-sided Wilcoxon test). Each dot represents a probe and the data points marked with crosses represent probes for Xist. The horizontal dashed lines indicate the significance level at which probe intensities presented a non-overlapping distribution between the sexes; probes lying on this line show higher expression in one sex relative to the other in all possible combinations of individual comparisons. The vertical dashed lines mark the fold-change +/−4 (i.e. 2 on log₂ scale), included in the figure for the sake of comparisons.