A Model of the Kdm5c escape domain. A: Depletion of the repressive histone marks macroH2A1 and H3K27me3 in the Kdm5c domain (liver ChIP data: GSM469459 and GSM517918). Genes: 1: Iqseq2, 2: Kdm5c, 3: D930009K15Rik, 4: 2810454L23Rik, 5: 1441020 _at (Intergenic), 6: 2900056M20Rik, 7: Tspyl2, 8: Gpr173. B: The schematic figure places Kdm5c (red) and the nearby-located female-biased non-coding genes (green) in a loop-out escape model, based on a general model of escape domains. The light grey area symbolises a transcriptionally silenced X-inactive territory. The chromosomal region containing the known escapee genes Kdm5c (2) and D930009K15Rik (3) is depleted of repressive marks and loops out from the silenced territory. 2810454L23Rik (4), 1441020 _at (5) and 2900056M20Rik (6) are situated in the transition region between active and inactive chromosomal domains, producing variable and less robust female-bias. The coding genes located upstream (Iqsec2) and downstream (Tspyl2) of the Kdm5c escape domain have previously been shown to be inactivated (black).