TY - JOUR AU - Yan, Liangzhen AU - Yang, Pengcheng AU - Jiang, Feng AU - Cui, Na AU - Ma, Enbo AU - Qiao, Chuanling AU - Cui, Feng PY - 2012 DA - 2012/11/10 TI - Transcriptomic and phylogenetic analysis of Culex pipiens quinquefasciatus for three detoxification gene families JO - BMC Genomics SP - 609 VL - 13 IS - 1 AB - The genomes of three major mosquito vectors of human diseases, Anopheles gambiae, Aedes aegypti, and Culex pipiens quinquefasciatus, have been previously sequenced. C. p. quinquefasciatus has the largest number of predicted protein-coding genes, which partially results from the expansion of three detoxification gene families: cytochrome P450 monooxygenases (P450), glutathione S-transferases (GST), and carboxyl/cholinesterases (CCE). However, unlike An. gambiae and Ae. aegypti, which have large amounts of gene expression data, C. p. quinquefasciatus has limited transcriptomic resources. Knowledge of complete gene expression information is very important for the exploration of the functions of genes involved in specific biological processes. In the present study, the three detoxification gene families of C. p. quinquefasciatus were analyzed for phylogenetic classification and compared with those of three other dipteran insects. Gene expression during various developmental stages and the differential expression responsible for parathion resistance were profiled using the digital gene expression (DGE) technique. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-13-609 DO - 10.1186/1471-2164-13-609 ID - Yan2012 ER -