Table 1 Classification of detoxification gene families in Drosophila melanogaster , Anopheles gambiae , Aedes aegypti , and Culex pipiens quinquefasciatus

CCE

Dietary/detoxification^*

B class (α-esterases)

13

16

22

30 (18)

Hormone/semiochemical processing

D class (integument esterases)

3

0

0

1 (0)

E class (β-esterases)

2

4

2

3 (3)

F class (dipteran JH esterases)

3

6

7

13 (5)

G class (lepidopteran JH esterases)

0

4

6

9 (6)

Neuro/developmental

H class (glutactins)

5

10

7

6 (5)

I class (unknown)

1

1

1

1 (1)

J class (acetylcholinesterases)

1

2

2

2 (2)

K class (gliotactins)

1

1

1

1 (1)

L class (neuroligins)

4

5

5

3 (3)

M class (neurotactins)

2

2

2

2 (2)

Total

35

51

55

71 (46)

P450

CYP2

6

10

11

14 (12)

CYP3 (include CYP6 and CYP9)

36

42

84

88 (72)

CYP4

32

45

59

83 (58)

Mitochondrial

11

9

10

11 (8)

Total

85

106

164

196 (150)

GST

Delta

11

12

8

14 (13)

Epsilon

14

8

8

10 (6)

Omega

5

1

1

1 (1)

Sigma

1

1

1

1 (1)

Theta

4

2

4

6 (6)

Zeta

2

1

1

0 (0)

Others

0

3

3

3 (2)

Total

37

28

26

35 (29)