Table 1 List of all the aminoacyl tRNA synthetases and their associated proteins, aaRS paralogs and editing domains with their CDD domain assignments and subcellular localization
From: Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from Leishmania major
| Â | Gene name | Length (aa) | HMM based function assignment | E-value# | Swissprot function assignment | Subcellular location (PSORT II) | CDD based domain assignment |
|---|---|---|---|---|---|---|---|
CLASS I aaRS | LmjF.12.0250 | 784 | Cysteinyl-tRNA synthetase | 1.00E-191 | Cysteinyl-tRNA synthetase | Cytosol | CysRS_Core; anticodon_la_like_superfamily |
LmjF.15.1440 | 570 | Glutaminyl-tRNA synthetase | 8.70E-208 | Glutaminyl-tRNA synthetase | Cytosol | GlnRS_core; GlnRS_core; tRNA_synt_Ic_C_superfamily | |
LmjF.30.3240 | 594 | Glutaminyl-tRNA synthetase | 7.00E-079 | Glutaminyl-tRNA synthetase | Cytosol | GlnRS_core; GlnRS_core; tRNA_synt_Ic_C_superfamily | |
LmjF.27.1310 | 692 | Arginyl-tRNA synthetase | 2.00E-151 | Arginyl-tRNA synthetase | Cytosol | Arg_tRNA_synt_N; ArgRS_Core; anticodon_Ia_like_superfamily | |
LmjF.36.5620 | 1009 | Isoleucyl-tRNA synthetase | 0 | Isoleucyl-tRNA synthetase | Cytosol | IleRS_Core; Anticodon_Ia_like_superfamily | |
LmjF.13.1100 | 1075 | Leucyl-tRNA synthetase | 3.70E-140 | Leucyl-tRNA synthetase | Cytosol | IleRS_Core; Anticodon_Ia_like_superfamily | |
LmjF.21.0810* | 747 | Methionyl-tRNA synthetase | 6.00E-145 | Methionyl-tRNA synthetase | Cytosol | MetRS_Core_superfamily; Anticodon_Ia_Met | |
LmjF.23.0300 | 412 | Tryptophanyl-tRNA synthetase | 1.90E-062 | Tryptophanyl-tRNA synthetase | Cytosol | TrpRS_core | |
LmjF.29.0060 | 480 | Tryptophanyl-tRNA synthetase | 1.70E-095 | Tryptophanyl-tRNA synthetase | Mitochondrial | TrpRS_core | |
LmjF.14.1370* | 682 | Tyrosyl-tRNA synthetase | 1.10E-051 | Tyrosyl-tRNA synthetase | Endoplasmic reticulum | TyrRS_core; TyrRS_core | |
LmjF.30.3130 | 967 | Valyl-tRNA synthetase | 0 | Valyl-tRNA synthetase | Cytosol | ValRS_core; anticodon_Ia_Val; Val_tRNA_synt_C_superfamily | |
CLASS II aaRS | LmjF.22.1540 | 962 | Alanyl-tRNA synthetase | 3.10E-262 | Alanyl-tRNA synthetase | Cytosol | AlaRS_core; tRNA_SAD |
LmjF.30.0460 | 550 | Aspartyl-tRNA synthetase | 3.90E-106 | Aspartyl-tRNA synthetase | Cytosol | AspRS_cyto_N; AsxRS_Core | |
LmjF.21.0895 | 641 | Aspartyl-tRNA synthetase | 5.70E-097 | Aspartyl-tRNA synthetase | Mitochondrial | AspRS_cyto_N; ClassII_aaRS_like_core_superfamily; ClassII_aaRS_like_core_superfamily | |
LmjF.34.2340 | 890 | Asparaginyl-tRNA synthetase | 2.40E-144 | Asparaginyl-tRNA synthetase | Cytosol | tRNA_synt_Ic_R1_superfamily; AsnRS_cyto_like_N; AsxRS_core | |
LmjF.36.3840 | 628 | Glycyl-tRNA synthetase | 5.10E-056 | Glycyl-tRNA synthetase | Cytosol | GlyRS_core; HGTP_anticodon | |
LmjF.30.0130 | 586 | Lysyl-tRNA synthetase | 8.20E-184 | Lysyl-tRNA synthetase | Cytosol | LysRS_N; LysRS_Core | |
LmjF.15.0230 | 536 | Lysyl-tRNA synthetase | 9.30E-148 | Lysyl-tRNA synthetase | Cytosol | LysRS_N; LysRS_Core | |
LmjF.19.1040 | 633 | Phenylalanyl-tRNA synthetase | 3.20E-053 | Phenylalanyl-tRNA synthetase | Cytosol | B3_4_superfamily; B5_superfamily; PheRS_beta_core | |
LmjF.32.0870 | 499 | Phenylalanyl-tRNA synthetase | 5.90E-052 | Phenylalanyl-tRNA synthetase | Cytosol | PheRS_alpha_core | |
LmjF.18.1210 | 731 | Prolyl-tRNA synthetase | 1.30E-188 | Prolyl-tRNA synthetase | Cytosol | Ybak_like_superfamily; ProRS_arch_euk; HGTP_anticodon_superfamily | |
LmjF.18.1220 | 731 | Prolyl-tRNA synthetase | 1.20E-190 | Prolyl-tRNA synthetase | Cytosol | Ybak_like_superfamily; ProRS_arch_euk; HGTP_anticodon_superfamily | |
LmjF.11.0100 | 474 | Seryl-tRNA synthetase | 4.40E-135 | Seryl-tRNA synthetase | Cytosol | Seryl_tRNA_N_superfamily; SerRS_Core | |
LmjF.30.0630 | 473 | Histidyl-tRNA synthetase | 2.30E-103 | Histidyl-tRNA synthetase | Cytosol | HisRS_Core; HisRS_anticodon | |
LmjF.35.1410 | 787 | Threonyl-tRNA synthetase | 3.20E-252 | Threonyl-tRNA synthetase | Cytosol | TGS_superfamily; tRNA_SAD; ThrRS_Core; HGTP_anticodon | |
Non-canonical | LmjF.09.0950 | 595 | O-Phosphoseryl-tRNA Selenium transferase | 9.10E-127 | SLA/LP autoantigen-like protein | Nuclear | Selenium_SpcS |
aaRS associated proteins | LmjF.22.0470 | 426 | EMAP-II like | 1.20E-023 | Hypothetical, Conserved | Extracellular | tRNA_binding_domain_superfamily |
LmjF.16.1130 | 180 | EMAP-II like | 1.20E-015 | Tyrosyl/methionyl-tRNA synthetase | Cytosol | tRNAbindingdomain_superfamily | |
AsnRS paralog | LmjF.26.0830 | 353 | Asparagine Synthetase A | 2.00E-002 | Aspartate, ammonia ligase | Mitochondrial | ClassII_aaRS_like_core_superfamily |
Trans Editing domains | LmjF.15.0690 | 491 | AlaX | 3.90E-028 | Hypothetical, conserved | Cytosol | tRNA_SAD_superfamily |
LmjF.03.0710 | 253 | YbaK | 2.20E-002 | Hypothetical, conserved | Cytosol | Ybak_like_superfamily | |
LmjF.21.0910 | 275 | YbaK | 7.20E-003 | Hypothetical, conserved | Cytosol | Ybak_like_superfamily | |
LmjF.36.2730 | 152 | Dtda | 1.00E-026 | D-tyrosine deacylase | Cytosol | Dtyr_deacylase | |
LmjF.34.3360* | 211 | Dtda | 5.40E-020 | Hypothetical, conserved | Cytosol | Dtyr_deacylase_superfamily |