TY - JOUR AU - Go, Jennifer T. AU - Belisle, Sarah E. AU - Tchitchek, Nicolas AU - Tumpey, Terrence M. AU - Ma, Wenjun AU - Richt, Juergen A. AU - Safronetz, David AU - Feldmann, Heinz AU - Katze, Michael G. PY - 2012 DA - 2012/11/15 TI - 2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models JO - BMC Genomics SP - 627 VL - 13 IS - 1 AB - The 2009 pandemic H1N1 influenza virus emerged in swine and quickly became a major global health threat. In mouse, non human primate, and swine infection models, the pH1N1 virus efficiently replicates in the lung and induces pro-inflammatory host responses; however, whether similar or different cellular pathways were impacted by pH1N1 virus across independent infection models remains to be further defined. To address this we have performed a comparative transcriptomic analysis of acute phase responses to a single pH1N1 influenza virus, A/California/04/2009 (CA04), in the lung of mice, macaques and swine. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-13-627 DO - 10.1186/1471-2164-13-627 ID - Go2012 ER -