Figure 6

CA04 virus induces different RXR signaling-mediated responses in each species. A) Average log₁₀(ratio) expression of 31 LXR/RXR DE genes induced by CA04 virus. In mice and swine, infected lung gene expression is referenced to specie-matched mock at each time point. In macaques, infected lung gene expression is relative to an uninfected lung reference pool at each time point. Red indicates expression was increased relative to the control reference and green indicates that expression was decreased relative to the control reference. Saturation is 4-fold. B) Average log₁₀(ratio) expression of 12 VDR/RXR DE genes induced by CA04 virus. In mice and swine, infected lung gene expression is referenced to specie-matched mock at each time point. In macaques, infected lung gene expression is relative to an uninfected lung reference pool at each time point. Red indicates expression was increased relative to the control reference and green indicates that expression was decreased relative to the control reference. Saturation is 4-fold. The association of each DE gene within a given species is shown on the left; blue denotes differential expression and gray denotes no differential expression. The following abbreviations are used: Mm, Mus musculus (mouse); Mf, Macaca fascicularis (macaque); and Ss, Sus scrofa (swine).