Example of Pfam and CDD coverage of a protein sequence. A protein sequence RcsC from Escherichia coli (GI: 145698285) is covered by four Pfam domain profiles: HisKA, HATPase_c, RcsC and Response_reg. Two transmembrane regions (TM) identified in this sequence by the TMHMM program are shown as grey rectangles. Small (<50 a.a.) interdomain regions are shown as grey lines. Large (>50 a.a.) interdomain regions are shown as black lines with a question mark. CDD profiles constructed from corresponding Pfam and SMART domain models are confirmatory (redundant) and the only new information is provided by one additional profile, PRK10841, which covers the entire sequence.