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Table 2 Putative LEF1/TCF target genes that encode proteins with specific neuronal functions

From: Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability

No.

Gene symbol (RGD)

Protein name; description

Voltage-gated cation channels

1

Cacna1g

Ca2+ channel, voltage-gated, α1G subunit

2

Cacna2d1

Ca2+ channel, voltage-gated, α2/δ1 subunit

3

Cacna2d2

Ca2+ channel, voltage-gated, α2/δ2 subunit

4

Kcna1

K+ voltage-gated, shaker-related subfamily member 1

5

Kcna6

K+ voltage-gated, shaker-related subfamily member 6

6

Kcnh4

K+ voltage-gated, subfamily H member 4

7

Kcnh8

K+ voltage-gated, subfamily H member 8

8

Kcnj3

K+ inwardly rectifying channel, subfamily J member 3

9

Scn8a

Na+ voltage-gated, type VIII, alpha subunit

Neurotransmitter receptors

10

Cnr1

Cannabinoid CB1 receptor; metabotropic

11

Drd3

Dopamine D3 receptor; metabotropic

12

Gabra3

GABAAα3 receptor; ionotropic (Cl-)

13

Gabrg2

GABAAγ2 receptor; ionotropic (Cl-)

14

Glra1

Glycine α1 receptor; ionotropic

15

Gria3

Glutamate AMPA 3 receptor; ionotropic

16

Grid2

Glutamate δ2 receptor; ionotropic

17

Grik3

Glutamate kainate 3 receptor; ionotropic

18

Htr1b

5-hydroxytryptamine (serotonin) 1B receptor; metabotropic

19

Htr3a

Serotonin 3A receptor; ionotropic

20

Htr3b

Serotonin 3B receptor; ionotropic

Synaptic vesicle proteins

21

Syt1

Synaptotagmin I; membrane protein, Ca2+ sensor involved in vesicle trafficking and neurotransmitter release

22

Syt4

Synaptotagmin IV; membrane protein, vesicle trafficking and neurotransmitter release

23

Syt5

Synaptotagmin V; membrane protein, Ca2+ sensor involved in vesicle trafficking and neurotransmitter release

24

Syt6

Synaptotagmin VI; membrane protein, Ca2+ sensor involved in vesicle trafficking and neurotransmitter release

25

Syt7

Synaptotagmin VII; membrane protein, Ca2+ sensor involved in vesicle trafficking and neurotransmitter release

26

Syp

Synaptophysin; synaptic vesicle organization

27

Vamp2

Vesicle-associated membrane protein 2; vesicle transport and membrane fusion during exocytosis

28

Vamp3

Vesicle-associated membrane protein 3; vesicle transport and membrane fusion during exocytosis

Structural synaptic proteins

29

Cdh2

Cadherin 2 (alias N-cadherin); hemophilic cell adhesion molecule in excitatory synapses

30

Cnksr2

Connector enhancer of kinase suppressor of Ras 2; scaffold protein, complex assembly of synaptic proteins

31

Dfnb31

Deafness autosomal recessive 31; PDZ scaffold protein, facilitates synaptic transmission

32

Gabarap

GABAA receptor-associated protein; involved in clustering of neurotransmitter receptors

33

Lin7a

Homolog a of C. elegans lin-7; PDZ scaffold protein, localizes vesicles and receptors to the plasma membrane

34

Map1b

Microtubule-associated protein; involved in synaptic plasticity

35

Mpdz

Multiple PDZ domain protein; PDZ scaffold protein, component of NMDA receptor signaling complex

36

Nlgn1

Neuroligin 1; synaptic cell adhesion molecule, maintains synaptic junctions by binding β-neurexins

37

Nlgn2

Neuroligin 2; synaptic cell-adhesion molecule, maintains synaptic junctions by binding β-neurexins

38

Nrxn3

Neurexins 3; synaptic cell-adhesion molecule; maintains synaptic junctions by binding neuroligins

Other proteins involved in modulation of signal transmission

39

Gjd2

Gap junction protein delta; member of the connexin family, in gap-junction channels of electrical synapses

40

App

Amyloid β (A4) precursor protein; cell surface receptor involved in synaptic plasticity

41

Calb2

Calbindin 2 (alias calretinin); Ca2+-binding protein, modulates neuronal excitability

  1. The gene symbols are based on the Rat Genome Database (RGD).